{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T04:35:00Z","timestamp":1745469300743,"version":"3.40.4"},"reference-count":26,"publisher":"S. Karger AG","issue":"3-4","license":[{"start":{"date-parts":[[2013,12,10]],"date-time":"2013-12-10T00:00:00Z","timestamp":1386633600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2013,12,10]],"date-time":"2013-12-10T00:00:00Z","timestamp":1386633600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur Neurol"],"published-print":{"date-parts":[[2014]]},"abstract":"<jats:p>&lt;b&gt;&lt;i&gt;Objective:&lt;\/i&gt;&lt;\/b&gt; To examine whether there are clinical features in Japanese patients with both neurodegenerative diseases and cancers. &lt;b&gt;&lt;i&gt;Methods:&lt;\/i&gt;&lt;\/b&gt; We analyzed the clinical characteristics of consecutive Japanese patients with neurodegenerative diseases during the past 5 years, including amyotrophic lateral sclerosis (ALS), Parkinson's disease (PD), dementia with Lewy bodies, progressive supranuclear palsy (PSP), corticobasal degeneration (CBD), and multiple system atrophy (MSA). &lt;b&gt;&lt;i&gt;Results:&lt;\/i&gt;&lt;\/b&gt; Out of 292 patients, 39 patients had cancers, including a past history, as follows: ALS, n = 16; PD, n = 8; PSP, n = 7; CBD, n = 1, and MSA, n = 7. About 10% of patients with neurodegenerative diseases developed cancer after onset of the disease; about 30% of patients with ALS, PD, or PSP occurring with cancers died of cancer. Gastric cancer was most common before the onset of ALS (62.5%) but did not develop after the onset of ALS. Conversely, PD patients frequently developed gastric cancers after the onset of neurological signs (60.0%) in spite of no cancer before the onset of PD. The proportion of breast cancer in MSA (45.5%) was significantly higher than in other neurodegenerative diseases. &lt;b&gt;&lt;i&gt;Conclusion:&lt;\/i&gt;&lt;\/b&gt; ALS, PD, or MSA patients with cancer showed clinical characteristics unique to each neurodegenerative disease in Japan compared to other countries.<\/jats:p>","DOI":"10.1159\/000353995","type":"journal-article","created":{"date-parts":[[2013,12,10]],"date-time":"2013-12-10T07:38:51Z","timestamp":1386661131000},"page":"99-105","source":"Crossref","is-referenced-by-count":2,"title":["Clinical Features in Association with Neurodegenerative Diseases and Malignancies"],"prefix":"10.1159","volume":"71","author":[{"given":"Ichiro","family":"Nozaki","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuko","family":"Kato-Motozaki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tokuhei","family":"Ikeda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Atsuro","family":"Tagami","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazuya","family":"Takahashi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chiho","family":"Ishida","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kiyonobu","family":"Komai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2013,12,10]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1093\/jjco\/hyr184"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0404.2010.01442.x"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1111\/j.1479-8301.2012.00415.x"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1080\/146608200300079536"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.55.3.181"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000187889.17253.b1"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.47.1.1"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1002\/ana.10570"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000324625.00404.15"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410410608"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1097\/00001648-200203000-00010"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e3181c91873"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1159\/000097851"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjc.6602279"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000277638.63767.b8"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1007\/s10552-009-9497-6"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1159\/000331489"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1093\/jjco\/hyn061"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.166.17.1871"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1007\/s004150070092"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.2325\/jbcs.12.57"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1016\/j.jns.2005.11.016"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1016\/j.anl.2011.01.005"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.24760"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.5402\/2012\/960867"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.55.7.616"}],"container-title":["European Neurology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/353995","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/353995","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/353995","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T18:41:04Z","timestamp":1745433664000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000353995"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,12,10]]},"references-count":26,"journal-issue":{"issue":"3-4","published-online":{"date-parts":[[2014,4,1]]},"published-print":{"date-parts":[[2014,4,3]]}},"URL":"https:\/\/doi.org\/10.1159\/000353995","archive":["Portico"],"relation":{},"ISSN":["0014-3022","1421-9913"],"issn-type":[{"type":"print","value":"0014-3022"},{"type":"electronic","value":"1421-9913"}],"subject":[],"published":{"date-parts":[[2013,12,10]]}}}