{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T10:31:40Z","timestamp":1761129100241,"version":"3.40.4"},"reference-count":17,"publisher":"S. Karger AG","issue":"3","license":[{"start":{"date-parts":[[2013,1,1]],"date-time":"2013-01-01T00:00:00Z","timestamp":1356998400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2013,1,1]],"date-time":"2013-01-01T00:00:00Z","timestamp":1356998400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cardiology"],"published-print":{"date-parts":[[2013]]},"abstract":"<jats:p>Objectives: Aortic valve stenosis (AS) causes cardiac fibrosis and left ventricular hypertrophy, and over time heart failure can occur. To date, a reliable marker to predict progression of AS or the development of heart failure is still lacking. In this study, we addressed the hypothesis that fibulin-1 levels reflect myocardial fibrosis. Methods: Patients undergoing heart surgery at the Odense University were investigated. By 2012 data on outcome were obtained. Results: In 293 patients, plasma fibulin-1 levels were measured. Patients with AS or atrial fibrillation (AF) had significantly higher fibulin-1 levels compared to those with coronary artery disease only (p = 0.005). Patients with preoperatively diagnosed chronic AF had significantly higher levels of fibulin-1 compared to those without (p = 0.004). Plasma fibulin-1 levels showed no relationship to echocardiographic size and had no impact on outcome, death or other adverse events. Conclusion: This study shows that plasma fibulin-1 levels are increased in patients with AS and AF compared to patients with coronary disease only. Our study results suggest fibulin-1, a vascular extracellular matrix (ECM) protein, as a marker of ECM turnover perhaps due to the increased myocardial stretch that is related to pressure overload.<\/jats:p>","DOI":"10.1159\/000354217","type":"journal-article","created":{"date-parts":[[2013,9,18]],"date-time":"2013-09-18T06:56:49Z","timestamp":1379487409000},"page":"202-206","source":"Crossref","is-referenced-by-count":13,"title":["Aortic Valve Stenosis and Atrial Fibrillation Influence Plasma Fibulin-1 Levels in Patients Treated with Coronary Bypass Surgery"],"prefix":"10.1159","volume":"126","author":[{"given":"Maria Lyck","family":"Hansen","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jordi S.","family":"Dahl","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"W. Scott","family":"Argraves","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akhmadjon","family":"Irmukhamedov","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lars Melholt","family":"Rasmussen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2013,9,18]]},"reference":[{"doi-asserted-by":"publisher","key":"ref1","DOI":"10.1038\/nrcardio.2010.202"},{"doi-asserted-by":"publisher","key":"ref2","DOI":"10.1172\/JCI31044"},{"doi-asserted-by":"publisher","key":"ref3","DOI":"10.1093\/cvr\/cvq308"},{"doi-asserted-by":"publisher","key":"ref4","DOI":"10.1016\/S0140-6736(09)60211-7"},{"doi-asserted-by":"publisher","key":"ref5","DOI":"10.1083\/jcb.111.6.3155"},{"doi-asserted-by":"publisher","key":"ref6","DOI":"10.1161\/JAHA.112.003889"},{"doi-asserted-by":"publisher","key":"ref7","DOI":"10.1016\/j.ejheart.2006.05.004"},{"doi-asserted-by":"publisher","key":"ref8","DOI":"10.1016\/j.atherosclerosis.2012.01.045"},{"doi-asserted-by":"publisher","key":"ref9","DOI":"10.1373\/clinchem.2011.162966"},{"doi-asserted-by":"publisher","key":"ref10","DOI":"10.1007\/s00441-009-0823-9"},{"doi-asserted-by":"publisher","key":"ref11","DOI":"10.1371\/journal.pone.0013360"},{"doi-asserted-by":"publisher","key":"ref12","DOI":"10.1016\/j.jacc.2012.02.093"},{"doi-asserted-by":"publisher","key":"ref13","DOI":"10.1161\/CIRCULATIONAHA.104.495903"},{"doi-asserted-by":"publisher","key":"ref14","DOI":"10.1177\/43.4.7534784"},{"doi-asserted-by":"publisher","key":"ref15","DOI":"10.1016\/j.ahj.2006.10.005"},{"doi-asserted-by":"publisher","key":"ref16","DOI":"10.1016\/j.ejheart.2006.08.004"},{"doi-asserted-by":"publisher","key":"ref17","DOI":"10.1160\/TH12-05-0310"}],"container-title":["Cardiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/354217","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/354217","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/354217","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T18:42:59Z","timestamp":1745433779000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000354217"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013]]},"references-count":17,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2013,10,1]]},"published-print":{"date-parts":[[2013,10,30]]}},"URL":"https:\/\/doi.org\/10.1159\/000354217","archive":["Portico"],"relation":{},"ISSN":["0008-6312","1421-9751"],"issn-type":[{"type":"print","value":"0008-6312"},{"type":"electronic","value":"1421-9751"}],"subject":[],"published":{"date-parts":[[2013]]}}}