{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T04:35:13Z","timestamp":1745469313440,"version":"3.40.4"},"reference-count":33,"publisher":"S. Karger AG","issue":"1","license":[{"start":{"date-parts":[[2013,9,7]],"date-time":"2013-09-07T00:00:00Z","timestamp":1378512000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/3.0\/"},{"start":{"date-parts":[[2013,9,7]],"date-time":"2013-09-07T00:00:00Z","timestamp":1378512000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Dement Geriatr Cogn Disord Extra"],"abstract":"<jats:p>&lt;b&gt;&lt;i&gt;Background:&lt;\/i&gt;&lt;\/b&gt; Some polymorphisms of the neurotrophin family have previously been investigated as candidate genes for Alzheimer's disease (AD). In the present study, we examined whether neurotrophin-3 (NTF-3) polymorphisms are genetic risk factors in patients with AD. &lt;b&gt;&lt;i&gt;Methods:&lt;\/i&gt;&lt;\/b&gt; From a sample of 507 subjects, we recruited 248 age-matched subjects divided into 2 groups: AD patients (n = 143) and normal controls (NCs) (n = 105). We identified 3 representative &lt;i&gt;NTF-3&lt;\/i&gt; single nucleotide polymorphisms (SNPs): rs6332, rs6489630, and rs4930767. Next, we statistically compared the allele frequencies of each SNP between the AD and NC groups in the&lt;b&gt; &lt;\/b&gt;early-onset (&lt;65 years) cases under a more limited age-matched condition. &lt;b&gt;&lt;i&gt;Results:&lt;\/i&gt;&lt;\/b&gt; We found a significant association between rs6332 and the total group of AD patients (p = 0.013) and significant associations between both rs6332 (p = 0.033) and rs6489630 (p = 0.035) and early-onset AD patients. &lt;b&gt;&lt;i&gt;Conclusion:&lt;\/i&gt;&lt;\/b&gt; These results suggest that &lt;i&gt;NTF-3&lt;\/i&gt; SNPs may not only be associated with AD itself, but also with early-onset AD in Japanese patients, assuming that the &lt;i&gt;NTF-3&lt;\/i&gt; gene may have age-related effects on neurodegenerative diseases.<\/jats:p>","DOI":"10.1159\/000354369","type":"journal-article","created":{"date-parts":[[2013,9,9]],"date-time":"2013-09-09T08:41:12Z","timestamp":1378716072000},"page":"272-280","source":"Crossref","is-referenced-by-count":7,"title":["Genetic Association between Neurotrophin-3 Polymorphisms and Alzheimer's Disease in Japanese Patients"],"prefix":"10.1159","volume":"3","author":[{"given":"Tomoyuki","family":"Nagata","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nobuto","family":"Shibata","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shunichiro","family":"Shinagawa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ritsuko","family":"Nakayama","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bolati","family":"Kuerban","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tohru","family":"Ohnuma","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Heii","family":"Arai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazuhiko","family":"Nakayama","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hisashi","family":"Yamada","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2013,9,7]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1016\/j.acn.2005.07.002"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1016\/S0028-3932(99)00079-2"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.58.12.1985"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1016\/0165-6147(91)90609-V"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1007\/BF00308809"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1126\/science.8346443"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1038\/ng.440"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1097\/YPG.0b013e3283586215"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddq142"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e31822f0435"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.57.6.846"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1016\/S0736-5748(00)00046-0"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1002\/jnr.21704"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1038\/nm.1912"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1038\/nm1239"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M413495200"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1016\/0149-7634(94)90043-4"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1016\/0888-7543(91)90436-I"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1159\/000343075"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1159\/000339358"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1159\/000094933"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1016\/S0304-3940(97)00953-1"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1038\/sj.mp.4000792"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1159\/000335355"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0447.1997.tb09654.x"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2007.11.004"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.1016\/j.pnpbp.2010.05.026"},{"key":"ref28","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.b.30632"},{"key":"ref29","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.34.7.939"},{"key":"ref30","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.58.12.1985"},{"key":"ref31","doi-asserted-by":"publisher","DOI":"10.1136\/jmg.2006.044883"},{"key":"ref32","doi-asserted-by":"publisher","DOI":"10.1001\/archgenpsychiatry.2010.194"},{"key":"ref33","doi-asserted-by":"publisher","DOI":"10.1126\/science.1135308"}],"container-title":["Dementia 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