{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,14]],"date-time":"2026-04-14T06:41:37Z","timestamp":1776148897490,"version":"3.50.1"},"reference-count":14,"publisher":"S. Karger AG","issue":"2","license":[{"start":{"date-parts":[[2013,8,28]],"date-time":"2013-08-28T00:00:00Z","timestamp":1377648000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/3.0\/"},{"start":{"date-parts":[[2013,8,28]],"date-time":"2013-08-28T00:00:00Z","timestamp":1377648000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Case Rep Dermatol"],"abstract":"<jats:p>Pyogenic granuloma (PG) is a vascular endothelial growth factor (VEGF)-related neoangiogenic process. Minor trauma, chronic irritation, certain drugs and pregnancy may favor PG. Viral triggers have not been reported up to date. A 52-year-old woman with hairy-cell leukemia presented because of a 3-month history of a giant pseudotumoral lesion on her left cheek. All prior antibacterial, antifungal and anti-inflammatory treatments had failed. Histology revealed PG with sparse and isolated epithelial cell aggregates. Immunohistochemistry (IHC) identified herpes simplex virus type-I (HSV-I) antigens in the nuclei and cytoplasm of normal-appearing as well as cytopathic epithelial cells, suggesting a chronic, low-productive HSV infection. No HSV-I signal was evidenced in the endothelial cells of the PG. Furthermore, IHC revealed VEGF in the HSV-I infected epithelial cells as well as within the PG endothelial cells. These results incited oral treatment with valaciclovir, and the PG promptly resolved after 2 weeks. These findings suggest that a chronic HSV-I infection might play an indirect, partial role in neoangiogenesis, presumably via HSV-I infection-related stimulation of keratinocytic VEGF production.<\/jats:p>","DOI":"10.1159\/000354570","type":"journal-article","created":{"date-parts":[[2013,8,28]],"date-time":"2013-08-28T14:35:37Z","timestamp":1377700537000},"page":"236-243","source":"Crossref","is-referenced-by-count":9,"title":["Herpes Simplex Virus Type-I and Pyogenic Granuloma: A Vascular Endothelial Growth Factor-Mediated Association"],"prefix":"10.1159","volume":"5","author":[{"given":"L.","family":"el Hayderi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D.","family":"Paurobally","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.F.","family":"Fassotte","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Andr\u00e9","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.E.","family":"Arrese","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"Sadzot-Delvaux","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Ruebben","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.F.","family":"Nikkels","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2013,8,28]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1016\/j.annder.2009.12.016"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.4103\/0973-029X.92978"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1038\/modpathol.2012.148"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1086\/426942"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1080\/000155599750009834"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2000.71.5.701"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.2217\/fmb.09.49"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajpath.2012.04.014"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1007\/s00705-008-0303-7"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1159\/000017944"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1155\/2012\/483439"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2010.07.011"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.1995.tb02682.x"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2005.07118.x"}],"container-title":["Case Reports in Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/354570","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/354570","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T18:46:43Z","timestamp":1745434003000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000354570"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,8,28]]},"references-count":14,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2013,8,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000354570","archive":["Portico"],"relation":{},"ISSN":["1662-6567"],"issn-type":[{"value":"1662-6567","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,8,28]]}}}