{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,17]],"date-time":"2026-03-17T22:50:56Z","timestamp":1773787856124,"version":"3.50.1"},"reference-count":40,"publisher":"S. Karger AG","issue":"4","license":[{"start":{"date-parts":[[2013,1,1]],"date-time":"2013-01-01T00:00:00Z","timestamp":1356998400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/3.0\/"},{"start":{"date-parts":[[2013,1,1]],"date-time":"2013-01-01T00:00:00Z","timestamp":1356998400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Obes Facts"],"published-print":{"date-parts":[[2013]]},"abstract":"<b><i>Objective:<\/i><\/b> The link between plasma resistin and obesity-related cardiometabolic disorders in children remains debatable. This study assessed the relationships of plasma resistin with cardiovascular risk factors, pro-inflammatory markers and insulin resistance index (HOMA-IR) in obese (Ob) adolescents and obese adolescents with metabolic syndrome (Ob-MS) compared to healthy controls (CO). <b><i>Methods:<\/i><\/b> 114 obese adolescents (60 Ob, age 13.6 \u00b1 0.9 years, BMI 28.0 \u00b1 2.2 kg\/m<sup>2<\/sup>, and 54 Ob-MS, age 13.8 \u00b1 1.0 years, BMI 32.5 \u00b1 4.8 kg\/m<sup>2<\/sup>) and 37 CO (age 13.7 \u00b1 0.8 years, BMI 22.8 \u00b1 0.8 kg\/m<sup>2<\/sup>) were studied. Anthropometrics, cardiac variables as well as fasting plasma concentrations of lipids, glucose, insulin, and adipocytokines (resistin, tumor necrosis factor-alpha (TNF-\u03b1), interleukin-6 (IL-6), C-reactive protein (CRP)) were measured. HOMA-IR was calculated, and the presence of MS was assessed. <b><i>Results:<\/i><\/b> Plasma resistin was significantly higher in Ob-MS than in both Ob and CO and was correlated with anthropometric, cardiovascular, pro-inflammatory markers and several components of MS as was HOMA-IR in Ob and Ob-MS. With increasing the number of MS components, plasma resistin, pro-inflammatory markers, and HOMA-IR were also increased. Multiple regression models highlighted significant correlation between resistin and both HOMA-IR (r = 0.40, p < 0.05) and systolic blood pressure (r = 0.63, p < 0.01) in Ob-MS. <b><i>Conclusion: <\/i><\/b>These results support the hypothesis that there is an association between circulating resistin and childhood obesity-related inflammatory and cardiometabolic events.<\/jats:p>","DOI":"10.1159\/000354574","type":"journal-article","created":{"date-parts":[[2013,8,19]],"date-time":"2013-08-19T07:38:39Z","timestamp":1376897919000},"page":"393-404","source":"Crossref","is-referenced-by-count":35,"title":["Correlation of Resistin with Inflammatory and Cardiometabolic Markers in Obese Adolescents with and without Metabolic Syndrome"],"prefix":"10.1159","volume":"6","author":[{"given":"Emna","family":"Makni","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wassim","family":"Moalla","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lamia","family":"Benezzeddine-Boussaidi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G\u00e9rard","family":"Lac","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zouhair","family":"Tabka","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohammed","family":"Elloumi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2013,8,16]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1464-5491.2006.01858.x"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-5448.2007.00271.x"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2008.01.035"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.3109\/17477160903281079"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa031049"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1111\/j.2047-6310.2012.00056.x"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.2337\/dc08-s273"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1016\/j.diabet.2007.09.004"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2008.06.082"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-5448.2008.00473.x"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2362.2007.01755.x"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1038\/35053000"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1111\/j.1462-8902.2004.00334.x"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1159\/000208517"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2002-021808"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2003-030519"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1089\/met.2010.0106"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1038\/ijo.2009.44"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.3967\/0895-3988.2011.01.002"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1093\/emboj\/19.15.4046"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000155620.10387.43"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2003.07.003"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1016\/j.metabol.2007.11.010"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1136\/adc.41.220.613"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1016\/j.metabol.2003.10.016"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.1053\/meta.2002.34029"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(07)60958-1"},{"key":"ref28","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ijo.0802539"},{"key":"ref29","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2007.09.021"},{"key":"ref30","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2265.2010.03953.x"},{"key":"ref31","doi-asserted-by":"publisher","DOI":"10.1016\/j.metabol.2010.03.023"},{"key":"ref32","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2012.05.063"},{"key":"ref33","doi-asserted-by":"publisher","DOI":"10.1017\/S0954422409990096"},{"key":"ref34","doi-asserted-by":"publisher","DOI":"10.2337\/diabetes.52.7.1611"},{"key":"ref35","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-003-1319-x"},{"key":"ref36","doi-asserted-by":"publisher","DOI":"10.1007\/s11739-008-0207-2"},{"key":"ref37","doi-asserted-by":"publisher","DOI":"10.2337\/db06-1656"},{"key":"ref38","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000147825.97879.E7"},{"key":"ref39","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.0000073999.07698.33"},{"key":"ref40","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.25.11.2081"}],"container-title":["Obesity 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