{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T13:44:20Z","timestamp":1762004660934,"version":"3.40.4"},"reference-count":41,"publisher":"S. Karger AG","issue":"3","license":[{"start":{"date-parts":[[2013,12,11]],"date-time":"2013-12-11T00:00:00Z","timestamp":1386720000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2013,12,11]],"date-time":"2013-12-11T00:00:00Z","timestamp":1386720000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Urol Int"],"published-print":{"date-parts":[[2014]]},"abstract":"<jats:p>&lt;b&gt;&lt;i&gt;Background and Objective:&lt;\/i&gt;&lt;\/b&gt; Prostate cancer is an endocrine-dependent tumor which is still under-investigated for physiopathology factors related to its natural history. The association of pretreatment total testosterone (TT) serum levels with prostate cancer is still a controversial topic. The objective of this study was to investigate potential associations and functional relationships of preoperative TT serum level and pathology-detected Gleason score (pGS). &lt;b&gt;&lt;i&gt;Materials and Methods:&lt;\/i&gt;&lt;\/b&gt; Pretreatment and pathological variables of 220 patients operated with radical prostatectomy were retrospectively reviewed. Age, prostate-specific antigen (PSA), percentage of positive biopsy cores (P+), biopsy Gleason score (bGS), pGS, TT and free testosterone were the continuous variables, while clinical stage (cT: cT1c, cT2\/3), biopsy Gleason pattern (bGP: \u22643+3, 3+4, &gt;3+4), pathology Gleason pattern (pGP: \u22643+3, 3+4, &gt;3+4), pathology stage (pT: pT2, pT3a, pT3b), pathology nodal staging (pN: pN0, pN1, pNx) and surgical margin invasion by cancer (R-, R+) were the categorical variables. Statistical methods were computed for assessing associations of TT and pGS; moreover, simple and multiple linear regression analysis (SLRA and MLRA) were used for assessing functional relationships of TT and pGS. &lt;b&gt;&lt;i&gt;Results:&lt;\/i&gt;&lt;\/b&gt; High-grade tumors (pGS \u22658.0) were associated with bGS &gt;6.0 (p &lt; 0.0001), pGP \u22653+4 (p &lt; 0.0001), P+ &gt;0.31% (p = 0.006), cT2\/3 (p = 0.01), TT &gt;15.5 nmol\/l (p = 0.0004) and, to a lesser extent, PSA &gt;6.27 \u03bcg\/l (p = 0.06). The odds ratio (OR) ranked as follows: 2.01 (PSA &gt;6.27 \u03bcg\/l), 2.88 (cT2\/3), 3.23 (P+ &gt;0.31%), 5.53 (TT &gt;15.5 nmol\/l) and 12.09 (pGP \u22653+4 and pGS \u22658.0). On SLRA, pGS variation was significantly predicted by bGS (p &lt; 0.0001), P+ (p &lt; 0.0001), PSA (p = 0.0005) and TT (p = 0.02); on MLRA, pGS variation was still significantly predicted by bGS (p &lt; 0.0001), P+ (p = 0.04), PSA (p = 0.03) and TT (p = 0.002). When bGS, P+, PSA and TT were dichotomized to their median value, only bGS (p &lt; 0.0001) and TT (p = 0.001) showed independence in predicting pGS variation. The best model for predicting pGS variations was by dichotomizing TT above its median (&gt;15.5 nmol\/l) because the predictive coefficient increased to 0.32, which means that patients with TT &gt;15.5 have a significantly higher estimated risk for high-grade pGS than patients with TT \u226415.5 nmol\/l (OR = 1.31). &lt;b&gt;&lt;i&gt;Conclusion:&lt;\/i&gt;&lt;\/b&gt; In a patient population undergoing radical prostatectomy, increased pretreatment serum measurements of TT are associated with and functionally related to high-grade pGS; moreover, baseline TT together with bGS and PSA are important factors for predicting pGS and assessing high-grade tumors. Baseline TT serum levels might have prognostic potential for assessing treatment response for continuous as well as intermittent androgen deprivation therapy.<\/jats:p>","DOI":"10.1159\/000354621","type":"journal-article","created":{"date-parts":[[2014,10,14]],"date-time":"2014-10-14T07:32:15Z","timestamp":1413271935000},"page":"269-278","source":"Crossref","is-referenced-by-count":20,"title":["Associations of Pretreatment Serum Total Testosterone Measurements with Pathology-Detected Gleason Score Cancer"],"prefix":"10.1159","volume":"93","author":[{"given":"Antonio 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