{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T16:27:06Z","timestamp":1791563226327,"version":"4.3.4"},"reference-count":49,"publisher":"S. Karger AG","issue":"6","license":[{"start":{"date-parts":[[2013,1,1]],"date-time":"2013-01-01T00:00:00Z","timestamp":1356998400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2013,1,1]],"date-time":"2013-01-01T00:00:00Z","timestamp":1356998400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Audiol Neurotol"],"published-print":{"date-parts":[[2013]]},"abstract":"<jats:p>&lt;b&gt;&lt;i&gt;Background:&lt;\/i&gt;&lt;\/b&gt; Although some therapies may be beneficial for some patients in reducing tinnitus, there is no curative therapy. Repetitive transcranial magnetic stimulation (rTMS) has been applied as a treatment for chronic tinnitus, but the effect remains controversial. &lt;b&gt;&lt;i&gt;Material and Methods:&lt;\/i&gt;&lt;\/b&gt; Fifty patients were treated with rTMS or placebo. Treatment consisted of 2,000 TMS pulses on each auditory cortex, at a rate of 1 Hz and an intensity of 110% of the individual motor threshold, on 5 consecutive days. rTMS and placebo effects were evaluated directly after treatment, after 1 week, and after 1, 3 and 6 months. Primary outcome was the Tinnitus Questionnaire (TQ). Secondary outcomes were the Tinnitus Handicap Inventory (THI) and a visual analogue scale. &lt;b&gt;&lt;i&gt;Results:&lt;\/i&gt;&lt;\/b&gt; At none of the follow-up evaluation moments a significant difference between rTMS and placebo was observed with respect to changes in TQ or THI scores relative to pretreatment scores. Multilevel modelling (MLM) analyses did not show a global treatment effect either. Patients with a higher degree of burden showed slightly greater improvement after rTMS (only significant on the THI with MLM analyses). &lt;b&gt;&lt;i&gt;Conclusion:&lt;\/i&gt;&lt;\/b&gt; Bilateral low-frequency rTMS of the auditory cortex was not effective in treating tinnitus.<\/jats:p>","DOI":"10.1159\/000354977","type":"journal-article","created":{"date-parts":[[2013,10,21]],"date-time":"2013-10-21T02:53:18Z","timestamp":1382323998000},"page":"362-373","source":"Crossref","is-referenced-by-count":47,"title":["Bilateral Low-Frequency Repetitive Transcranial Magnetic Stimulation of the Auditory Cortex in Tinnitus Patients Is Not Effective: A Randomised Controlled Trial"],"prefix":"10.1159","volume":"18","author":[{"given":"Carlijn E.L.","family":"Hoekstra","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huib","family":"Versnel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sebastiaan F.W.","family":"Neggers","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marlien E.F.","family":"Niesten","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gijsbert A.","family":"van Zanten","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2013,10,19]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1002%2Fjmri.21445"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.3109%2F03005369909090101"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1212%2FWNL.48.5.1398"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.3109%2F00206098409070084"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1159%2F000330882"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1016%2FS0140-6736%2812%2960469-3"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1017%2FS1755146300090041"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1159%2F000080267"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1073%2Fpnas.1018466108"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1097%2F01.mao.0000178146.91139.3c"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1016%2FS0079-6123%2807%2966032-4"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.tins.2004.08.010"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1468-1331.2006.01414.x"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.2044-8260.1988.tb00778.x"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.neuron.2007.06.026"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1136%2Fjnnp.2007.127712"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.otohns.2004.09.134"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.otohns.2006.12.007"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.neuroimage.2006.09.002"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1186%2F1471-2202-8-45"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.heares.2009.06.009"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.neuron.2010.12.002"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.otohns.2007.11.035"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.3389%2Ffnsys.2012.00011"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.neucli.2006.08.001"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.jad.2005.08.001"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1468-1331.2009.02730.x"},{"key":"ref28","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.anl.2010.09.007"},{"key":"ref29","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.neuroimage.2003.12.006"},{"key":"ref30","doi-asserted-by":"publisher","DOI":"10.1001%2Farchotol.1996.01890140029007"},{"key":"ref31","doi-asserted-by":"publisher","DOI":"10.1016%2FS0378-5955%2803%2900225-9"},{"key":"ref32","doi-asserted-by":"publisher","DOI":"10.1016%2FS0378-5955%2896%2900201-8"},{"key":"ref33","doi-asserted-by":"publisher","DOI":"10.1001%2Farchoto.2011.3"},{"key":"ref34","doi-asserted-by":"publisher","DOI":"10.1002%2Fana.10468"},{"key":"ref35","doi-asserted-by":"publisher","DOI":"10.1002%2Fhbm.20270"},{"key":"ref36","doi-asserted-by":"publisher","DOI":"10.1136%2Fjnnp.2006.095612"},{"key":"ref37","doi-asserted-by":"publisher","DOI":"10.1212%2FWNL.0b013e3182574ef9"},{"key":"ref38","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.specom.2004.02.004"},{"key":"ref39","doi-asserted-by":"publisher","DOI":"10.1523%2FJNEUROSCI.4028-10.2010"},{"key":"ref40","doi-asserted-by":"publisher","DOI":"10.1136%2Fjnnp.2006.105007"},{"key":"ref41","doi-asserted-by":"publisher","DOI":"10.1002%2F%28SICI%291097-0142%2819980515%2982%3A10%3C1904%3A%3AAID-CNCR13%3E3.0.CO%3B2-X"},{"key":"ref42","doi-asserted-by":"publisher","DOI":"10.1186%2F1471-2202-10-11"},{"key":"ref43","doi-asserted-by":"publisher","DOI":"10.1097%2F01.yct.0000235924.60364.27"},{"key":"ref44","doi-asserted-by":"publisher","DOI":"10.1016%2FS0079-6123%2807%2966043-9"},{"key":"ref45","doi-asserted-by":"publisher","DOI":"10.1097%2FMLG.0b013e31802f4154"},{"key":"ref46","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.clineuro.2011.03.015"},{"key":"ref47","doi-asserted-by":"publisher","DOI":"10.1002%2Fcncr.23622"},{"key":"ref48","doi-asserted-by":"publisher","DOI":"10.1016%2FS0168-5597%2897%2900096-8"},{"key":"ref49","doi-asserted-by":"publisher","DOI":"10.1371%2Fjournal.pmed.0020153"}],"container-title":["Audiology and Neurotology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/354977","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/354977","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T14:04:36Z","timestamp":1745417076000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000354977"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013]]},"references-count":49,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2013,11,1]]},"published-print":{"date-parts":[[2013,11,29]]}},"URL":"https:\/\/doi.org\/10.1159\/000354977","archive":["Portico"],"relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.718155507.793486793","asserted-by":"object"}]},"ISSN":["1420-3030","1421-9700"],"issn-type":[{"value":"1420-3030","type":"print"},{"value":"1421-9700","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013]]}}}