{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T04:33:09Z","timestamp":1745469189136,"version":"3.40.4"},"reference-count":35,"publisher":"S. Karger AG","issue":"2","license":[{"start":{"date-parts":[[2013,12,7]],"date-time":"2013-12-07T00:00:00Z","timestamp":1386374400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2013,12,7]],"date-time":"2013-12-07T00:00:00Z","timestamp":1386374400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Ophthalmic Res"],"published-print":{"date-parts":[[2014]]},"abstract":"<jats:p>&lt;b&gt;&lt;i&gt;Purpose:&lt;\/i&gt;&lt;\/b&gt; To investigate therapeutic ocular surface medium (TOSM), a potential physiological tear replacement therapy, for persistent epithelial defect (PED). &lt;b&gt;&lt;i&gt;Methods:&lt;\/i&gt;&lt;\/b&gt; 11 eyes of 10 patients with PED for \u22652 weeks without improvement despite conventional treatment were enrolled in a prospective pilot study of TOSM over 1 month. &lt;b&gt;&lt;i&gt;Results:&lt;\/i&gt;&lt;\/b&gt; Healing of the PED occurred in 3 out of the 11 eyes at 1, 2 and 4 weeks, respectively. At week 4, 2 eyes were almost healed (PED area \u22640.5 mm&lt;sup&gt;2&lt;\/sup&gt;). In 4 of the remaining 6 eyes, the PED area was reduced. Failure occurred in 1 case with end-stage ocular cicatricial pemphigoid and severe dry eye, and 1 patient withdrew due to a mild allergic reaction. There were no serious or irreversible side effects with TOSM. &lt;b&gt;&lt;i&gt;Conclusions:&lt;\/i&gt;&lt;\/b&gt; TOSM is a potential novel physiological therapy for PED that, unlike autologous serum, has the potential to be easily manufactured and widely available.<\/jats:p>","DOI":"10.1159\/000355065","type":"journal-article","created":{"date-parts":[[2017,4,18]],"date-time":"2017-04-18T21:44:23Z","timestamp":1492551863000},"page":"82-87","source":"Crossref","is-referenced-by-count":3,"title":["Clinical Study of Therapeutic Ocular Surface Medium for Persistent Epithelial 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