{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,17]],"date-time":"2026-02-17T03:30:02Z","timestamp":1771299002684,"version":"3.50.1"},"reference-count":18,"publisher":"S. Karger AG","issue":"3","license":[{"start":{"date-parts":[[2013,9,10]],"date-time":"2013-09-10T00:00:00Z","timestamp":1378771200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/3.0\/"},{"start":{"date-parts":[[2013,9,10]],"date-time":"2013-09-10T00:00:00Z","timestamp":1378771200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Case Rep Oncol"],"abstract":"<jats:p>&lt;b&gt;&lt;i&gt;Introduction:&lt;\/i&gt;&lt;\/b&gt; Carcinoma ex pleomorphic adenoma (CXPA) of the salivary glands has often a salivary duct carcinoma (SDC) component, which resembles ductal carcinoma of the breast and frequently overexpresses human epidermal growth factor receptor-2 (HER2). We report a case of metastatic CXPA with SDC component who was treated with trastuzumab-based chemotherapy and has had a durable complete response. &lt;b&gt;&lt;i&gt;Case Report:&lt;\/i&gt;&lt;\/b&gt; A 74-year-old man was diagnosed with CXPA of the right parotid gland. The resected tumor was histologically diagnosed as CXPA with a predominant SDC component that showed strong positivity for HER2 protein and &lt;i&gt;HER2&lt;\/i&gt; gene amplification. Multiple pulmonary metastatic lesions were detected after surgery, and combination chemotherapy with paclitaxel and trastuzumab was initiated. A complete response was confirmed after 7 treatment cycles, and no evidence of disease progression has been observed after 13 months of initiation of therapy. &lt;b&gt;&lt;i&gt;Conclusions:&lt;\/i&gt;&lt;\/b&gt; This report suggests a potential utility of trastuzumab-based chemotherapy for HER2-positive CXPA.<\/jats:p>","DOI":"10.1159\/000355219","type":"journal-article","created":{"date-parts":[[2013,9,11]],"date-time":"2013-09-11T00:21:08Z","timestamp":1378858868000},"page":"450-455","source":"Crossref","is-referenced-by-count":42,"title":["Complete Response to Trastuzumab-Based Chemotherapy in a Patient with Human Epidermal Growth Factor Receptor-2-Positive Metastatic Salivary Duct Carcinoma ex Pleomorphic Adenoma"],"prefix":"10.1159","volume":"6","author":[{"given":"Shigenori","family":"Kadowaki","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasushi","family":"Yatabe","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hitoshi","family":"Hirakawa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Azusa","family":"Komori","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chihiro","family":"Kondoh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasuhisa","family":"Hasegawa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kei","family":"Muro","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2013,9,10]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1053\/hupa.2001.25000"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0142(19960115)77:2<223::AID-CNCR1>3.0.CO;2-N"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19930901)72:5<1503::AID-CNCR2820720503>3.0.CO;2-K"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1016\/S0194-5998(03)01386-X"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.21116"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1053\/j.seminoncol.2008.03.009"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1078\/0344-0338-00136"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2559.2004.01781.x"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1016\/j.oraloncology.2009.05.635"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0b013e31820832a6"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1002\/hed.20614"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1007\/s12032-011-9884-1"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1002\/hed.20714"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1017\/S0022215108002314"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1186\/1758-3284-2-12"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2559.2012.04201.x"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200103153441101"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1016\/S1368-8375(03)00097-6"}],"container-title":["Case Reports in Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/355219","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/355219","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T18:06:10Z","timestamp":1745431570000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000355219"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,9,10]]},"references-count":18,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2013,12,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000355219","archive":["Portico"],"relation":{},"ISSN":["1662-6575"],"issn-type":[{"value":"1662-6575","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,9,10]]}}}