{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T04:33:15Z","timestamp":1745469195220,"version":"3.40.4"},"reference-count":25,"publisher":"S. Karger AG","issue":"4","license":[{"start":{"date-parts":[[2013,11,27]],"date-time":"2013-11-27T00:00:00Z","timestamp":1385510400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2013,11,27]],"date-time":"2013-11-27T00:00:00Z","timestamp":1385510400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neurodegener Dis"],"published-print":{"date-parts":[[2014]]},"abstract":"<jats:p>&lt;b&gt;&lt;i&gt;Backgound\/Objective:&lt;\/i&gt;&lt;\/b&gt; To determine the level of association between uptake of the amyloid positron emission tomography (PET) imaging agent [&lt;sup&gt;18&lt;\/sup&gt;F]flutemetamol and the level of amyloid-\u00df measured by immunohistochemical and histochemical staining in a frontal cortical region biopsy site. &lt;b&gt;&lt;i&gt;Methods:&lt;\/i&gt;&lt;\/b&gt; Seventeen patients with probable normal pressure hydrocephalus (NPH) underwent prospective [&lt;sup&gt;18&lt;\/sup&gt;F]flutemetamol PET and subsequent frontal cortical brain biopsy during ventriculoperitoneal shunting. Tissue amyloid-\u00df was evaluated using the monoclonal antibody 4G8, thioflavin S and Bielschowsky silver stain. &lt;b&gt;&lt;i&gt;Results:&lt;\/i&gt;&lt;\/b&gt; Four of the 17 patients (23.5%) had amyloid-\u00df pathology based on the overall pathology read and also showed increased [&lt;sup&gt;18&lt;\/sup&gt;F]flutemetamol uptake. [&lt;sup&gt;18&lt;\/sup&gt;F]Flutemetamol standardized uptake values from the biopsy site were significantly associated with biopsy specimen amyloid-\u00df levels (Pearson's r = 0.67; p = 0.006). There was also good correlation between the biopsy specimen amyloid-\u00df level and uptake of [&lt;sup&gt;18&lt;\/sup&gt;F]flutemetamol in the region contralateral to the biopsy site (r = 0.67; p = 0.006), as well as with composite cortical [&lt;sup&gt;18&lt;\/sup&gt;F]flutemetamol uptake (r = 0.65; p = 0.008). The blinded visual read showed a high level of agreement between all readers (&amp;#954; = 0.88). Two of 3 readers were in full agreement on all images; 1 reader disagreed on 1 of the 17 NPH cases. Blinded visual assessments of PET images by 1 reader were associated with 100% sensitivity to the overall pathology read, and assessments by the 2 others were associated with 75% sensitivity (overall sensitivity by majority read was 75%); specificity of all readers was 100%. &lt;b&gt;&lt;i&gt;Conclusions:&lt;\/i&gt;&lt;\/b&gt; [&lt;sup&gt;18&lt;\/sup&gt;F]Flutemetamol detects brain amyloid-\u00df in vivo and shows promise as a valuable tool to study and possibly facilitate diagnosis of Alzheimer's disease both in patients with suspected NPH and among the wider population.<\/jats:p>","DOI":"10.1159\/000355256","type":"journal-article","created":{"date-parts":[[2013,11,27]],"date-time":"2013-11-27T08:08:58Z","timestamp":1385539738000},"page":"237-245","source":"Crossref","is-referenced-by-count":16,"title":["Prospective Flutemetamol Positron Emission Tomography and Histopathology in Normal Pressure Hydrocephalus"],"prefix":"10.1159","volume":"13","author":[{"given":"Juha 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