{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T06:11:55Z","timestamp":1773295915136,"version":"3.50.1"},"reference-count":37,"publisher":"S. Karger AG","issue":"4","license":[{"start":{"date-parts":[[2013,1,1]],"date-time":"2013-01-01T00:00:00Z","timestamp":1356998400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2013,1,1]],"date-time":"2013-01-01T00:00:00Z","timestamp":1356998400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neuropsychobiology"],"published-print":{"date-parts":[[2013]]},"abstract":"<b><i>Background:<\/i><\/b> Autism spectrum disorder (ASD) is a neurobiological disorder characterized by distinctive impairments in cognitive function, language, and behavior. Linkage and population studies suggest a genetic association between solute carrier family 6 member 4 <i>(SLC6A4)<\/i> variants and ASD. <b><i>Method:<\/i><\/b> Logistic regression was used to identify associations between single-nucleotide polymorphisms (SNPs) and ASD with 3 alternative models (additive, dominant, and recessive). Linear regression analysis was performed to determine the influence of SNPs on Childhood Autism Rating Scale (CARS) scores as a quantitative phenotype. <b><i>Results:<\/i><\/b> In the present study, we examined the associations of SNPs in the <i>SLC6A4<\/i> gene and the fibrinogen alpha chain <i>(FGA)<\/i> gene. Logistic regression analysis showed a significant association between the risk of ASD and rs2070025 and rs2070011 in the <i>FGA<\/i> gene. The gene-gene interaction between <i>SLC6A4<\/i> and <i>FGA<\/i> was not significantly associated with ASD susceptibility. However, polymorphisms in both <i>SLC6A4 <\/i>and the <i>FGA<\/i> gene significantly affected the symptoms of ASD. <b><i>Conclusion:<\/i><\/b> Our findings indicate that <i>FGA<\/i> and <i>SLC6A4<\/i> gene interactions may contribute to the phenotypes of ASD rather than the incidence of ASD.<\/jats:p>","DOI":"10.1159\/000355299","type":"journal-article","created":{"date-parts":[[2013,11,1]],"date-time":"2013-11-01T09:12:03Z","timestamp":1383297123000},"page":"212-220","source":"Crossref","is-referenced-by-count":5,"title":["Association of the <b><i>FGA<\/i><\/b> and <b><i>SLC6A4<\/i><\/b> Genes with Autistic Spectrum Disorder in a Korean 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