{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,20]],"date-time":"2025-09-20T18:55:21Z","timestamp":1758394521478,"version":"3.40.4"},"reference-count":38,"publisher":"S. Karger AG","issue":"10","license":[{"start":{"date-parts":[[2013,1,1]],"date-time":"2013-01-01T00:00:00Z","timestamp":1356998400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2013,1,1]],"date-time":"2013-01-01T00:00:00Z","timestamp":1356998400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Oncol Res Treat"],"published-print":{"date-parts":[[2013]]},"abstract":"<jats:p>The peroxisome proliferator-activated receptor-&amp;#947; (PPAR&amp;#947;) belongs to the nuclear hormone receptor superfamily, and is expressed in adipose tissue, skeletal muscle, spleen, heart, liver, placenta, lung, and ovary. PPAR&amp;#947; is a critical regulator of inflammation, adipocyte differentiation, glucose homeostasis, and tumorigenesis. The mechanism of PPAR&amp;#947; on tumor suppression is still unclear, but plenty of evidence shows that PPAR&amp;#947; provides new therapeutic targets for cancer. Here we give a review of how PPAR&amp;#947; and its ligands regulate tumorigenesis by different pathways.<\/jats:p>","DOI":"10.1159\/000355328","type":"journal-article","created":{"date-parts":[[2013,9,26]],"date-time":"2013-09-26T14:05:43Z","timestamp":1380204343000},"page":"598-601","source":"Crossref","is-referenced-by-count":29,"title":["PPAR&amp;#947; against Tumors by Different Signaling Pathways"],"prefix":"10.1159","volume":"36","author":[{"given":"Zhi","family":"Zhang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ying","family":"Xu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qinggang","family":"Xu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yongzhong","family":"Hou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2013,9,17]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1016\/j.critrevonc.2005.08.011"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1006\/bbrc.2001.5602"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1161\/01.ATV.0000051382.28752.FE"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1093\/carcin\/bgs173"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2008.12.048"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1206400"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2005.01.019"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1093\/jjco\/hyf056"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjc.6602244"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1016\/S0090-4295(02)01747-8"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1159\/000353232"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.7150\/ijms.4455"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M210819200"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1206885"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0016179"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.4161\/cbt.11.12.15709"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1172\/JCI16575"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1016\/j.biotechadv.2011.08.001"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1002\/nbm.1484"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1007\/s10549-008-9944-1"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)81728-6"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1007\/s10456-008-9118-0"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-291X(02)00385-6"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.2174\/1568009611313040008"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1016\/j.yexmp.2011.09.007"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.1007\/s00432-011-0993-1"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.3892\/ijo.2011.1237"},{"key":"ref28","doi-asserted-by":"publisher","DOI":"10.1016\/j.canlet.2010.09.014"},{"key":"ref29","doi-asserted-by":"publisher","DOI":"10.1016\/j.lungcan.2005.10.010"},{"key":"ref30","doi-asserted-by":"publisher","DOI":"10.1016\/j.canlet.2008.10.023"},{"key":"ref31","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2011.06.026"},{"key":"ref32","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)00077-5"},{"key":"ref33","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.biochem.78.101807.093809"},{"key":"ref34","doi-asserted-by":"publisher","DOI":"10.1038\/onc.2013.135"},{"key":"ref35","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms2270"},{"key":"ref36","doi-asserted-by":"publisher","DOI":"10.1038\/nm.2349"},{"key":"ref37","doi-asserted-by":"publisher","DOI":"10.1038\/nm.2332"},{"key":"ref38","doi-asserted-by":"publisher","DOI":"10.1038\/nature10383"}],"container-title":["Oncology Research and Treatment"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/355328","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/355328","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T18:07:34Z","timestamp":1745431654000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000355328"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013]]},"references-count":38,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2013,10,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000355328","archive":["Portico"],"relation":{},"ISSN":["2296-5270","2296-5262"],"issn-type":[{"type":"print","value":"2296-5270"},{"type":"electronic","value":"2296-5262"}],"subject":[],"published":{"date-parts":[[2013]]}}}