{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T22:59:34Z","timestamp":1792623574542,"version":"4.5.0"},"reference-count":29,"publisher":"S. Karger AG","issue":"1-2","license":[{"start":{"date-parts":[[2013,10,29]],"date-time":"2013-10-29T00:00:00Z","timestamp":1383004800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2013,10,29]],"date-time":"2013-10-29T00:00:00Z","timestamp":1383004800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nephron Clin Pract"],"abstract":"<jats:p>&lt;b&gt;&lt;i&gt;Background\/Aims:&lt;\/i&gt;&lt;\/b&gt; The associations between major depression and chronic kidney disease (CKD) in patients with diabetes are incompletely characterized. Depressed patients with diabetes are known to have worse diabetes self-care, but it is not known whether this mediates the association between depression and CKD in this population. &lt;b&gt;&lt;i&gt;Methods:&lt;\/i&gt;&lt;\/b&gt; We conducted a cross-sectional study of the associations between major depressive symptoms and CKD in the Pathways Study (n = 4,082), an observational cohort of ambulatory diabetic patients from a managed care setting. Depression status was ascertained using the Patient Health Questionnaire-9 (PHQ-9). Stepwise logistic regression models examined the associations between depression and impaired estimated glomerular filtration rate (&lt;60 ml\/min\/1.73 m&lt;sup&gt;2&lt;\/sup&gt;) or microalbuminuria, after adjustment for demographics, CKD risk factors, and diabetes self-care variables. &lt;b&gt;&lt;i&gt;Results:&lt;\/i&gt;&lt;\/b&gt; Clinically significant depression symptoms (PHQ-9 \u226510) were associated with a greater risk of microalbuminuria after adjustment for demographic variables (OR 1.54, 95% CI 1.21-1.95) and traditional CKD risk factors (OR 1.36, 95% CI 1.04-1.77); this association persisted after additional adjustment for diabetes self-care (OR 1.34, 95% CI 1.02-1.75). Depression was not associated with impaired estimated glomerular filtration rate in any of the models. &lt;b&gt;&lt;i&gt;Conclusion:&lt;\/i&gt;&lt;\/b&gt; In this cohort of diabetic subjects, clinically significant depression symptoms were associated with microalbuminuria, which could not be entirely explained by differences in diabetes self-care.<\/jats:p>","DOI":"10.1159\/000355551","type":"journal-article","created":{"date-parts":[[2013,10,29]],"date-time":"2013-10-29T08:45:38Z","timestamp":1383036338000},"page":"106-112","source":"Crossref","is-referenced-by-count":19,"title":["Diabetes Self-Care, Major Depression, and Chronic Kidney Disease in an Outpatient Diabetic Population"],"prefix":"10.1159","volume":"124","author":[{"given":"Margaret K.","family":"Yu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wayne","family":"Katon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bessie A.","family":"Young","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2013,10,29]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1038\/ki.2013.77"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1755.2000.00059.x"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1755.2002.00411.x"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1053\/j.ajkd.2009.03.017"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1038\/ki.2010.38"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2010.619"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1038\/ki.2011.153"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1016\/j.genhosppsych.2009.11.018"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.24.6.1069"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.160.21.3278"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.27.9.2154"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.2337\/dc07-0158"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-134-2-200101160-00009"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-006-0252-1"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1001\/jama.293.2.217"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1016\/S0163-8343(03)00013-6"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2004030162"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1159\/000090112"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1053\/j.ajkd.2005.08.006"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.61.10.1042"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.23.7.943"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1007\/BF00844767"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.2215\/CJN.03840510"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.163.12.1440"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1001\/archinternmed.2010.334"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.1136\/heartjnl-2012-302920x.1"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbi.2009.04.011"},{"key":"ref28","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2008-2534"},{"key":"ref29","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-3223(03)00569-9"}],"container-title":["Nephron Clinical Practice"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/355551","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/355551","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T18:09:45Z","timestamp":1745431785000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000355551"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,10,29]]},"references-count":29,"journal-issue":{"issue":"1-2","published-online":{"date-parts":[[2013,12,1]]},"published-print":{"date-parts":[[2013,12,4]]}},"URL":"https:\/\/doi.org\/10.1159\/000355551","archive":["Portico"],"relation":{},"ISSN":["1660-2110"],"issn-type":[{"value":"1660-2110","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,10,29]]}}}