{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,11]],"date-time":"2025-07-11T10:23:44Z","timestamp":1752229424931,"version":"3.40.4"},"reference-count":39,"publisher":"S. Karger AG","issue":"5-6","license":[{"start":{"date-parts":[[2013,12,31]],"date-time":"2013-12-31T00:00:00Z","timestamp":1388448000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2013,12,31]],"date-time":"2013-12-31T00:00:00Z","timestamp":1388448000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Dement Geriatr Cogn Disord"],"published-print":{"date-parts":[[2014]]},"abstract":"<jats:p>&lt;b&gt;&lt;i&gt;Background\/Aims:&lt;\/i&gt;&lt;\/b&gt; Accurate diagnosis of sporadic early-onset Alzheimer's disease (EOAD) can be challenging, and cerebrospinal fluid (CSF) biomarkers may assist in this process. We compared CSF indices between three EOAD subtypes: amnestic, logopenic progressive aphasia (LPA), and posterior cortical atrophy (PCA). &lt;b&gt;&lt;i&gt;Methods:&lt;\/i&gt;&lt;\/b&gt; We identified 21 amnestic EOAD, 20 LPA, and 12 PCA patients with CSF data, which included amyloid \u03b2&lt;sub&gt;1-42&lt;\/sub&gt; (A\u03b242), total tau (t-tau), phospho-tau&lt;sub&gt;181&lt;\/sub&gt; (p-tau), and A\u03b242\/t-tau index (ATI) levels. &lt;b&gt;&lt;i&gt;Results:&lt;\/i&gt;&lt;\/b&gt; A\u03b242 and ATI levels were similar across groups, but t-tau and p-tau levels were significantly lower in PCA patients. &lt;b&gt;&lt;i&gt;Conclusions:&lt;\/i&gt;&lt;\/b&gt; The A\u03b242 and ATI data confirm the commonality of the A\u03b2 pathology in EOAD. The lower tau indices in PCA patients may reflect differences in the distribution of neurofibrillary tangles or rates of neurodegeneration.<\/jats:p>","DOI":"10.1159\/000355555","type":"journal-article","created":{"date-parts":[[2014,1,7]],"date-time":"2014-01-07T14:14:03Z","timestamp":1389104043000},"page":"307-314","source":"Crossref","is-referenced-by-count":23,"title":["Cerebrospinal Fluid Biomarkers in Clinical Subtypes of Early-Onset Alzheimer's Disease"],"prefix":"10.1159","volume":"37","author":[{"given":"Edmond","family":"Teng","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tritia R.","family":"Yamasaki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michelle","family":"Tran","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julia 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