{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T13:28:45Z","timestamp":1787318925471,"version":"build-2736575974"},"reference-count":22,"publisher":"S. Karger AG","issue":"5","license":[{"start":{"date-parts":[[2013,1,1]],"date-time":"2013-01-01T00:00:00Z","timestamp":1356998400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2013,1,1]],"date-time":"2013-01-01T00:00:00Z","timestamp":1356998400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Am J Nephrol"],"published-print":{"date-parts":[[2013]]},"abstract":"<jats:p>&lt;b&gt;&lt;i&gt;Background:&lt;\/i&gt;&lt;\/b&gt; Hepatitis C virus (HCV) infection is associated with increased mortality among hemodialysis (HD) patients. Guidelines from Kidney Disease: Improving Global Outcomes recommend that infected HD patients awaiting renal transplantation be treated for HCV and that clinicians decide whether to treat other infected patients on a case-by-case basis. We evaluated the extent and outcome of HCV therapy among HD patients. &lt;b&gt;&lt;i&gt;Methods:&lt;\/i&gt;&lt;\/b&gt; The Dialysis Outcomes and Practice Patterns Study is an observational study; 49,762 HD patients in 12 nations enrolled between 1996 and 2011. We reviewed HCV status, use of interferon or ribavirin, and survival over a median 1.4 years per study phase. &lt;b&gt;&lt;i&gt;Results:&lt;\/i&gt;&lt;\/b&gt; 4,735 patients (9.5%) were HCV+. Only 48 (1.0%) of the 4,589 HCV+ patients with prescription data were receiving antiviral medication. Among the subset of 617 HCV+ patients also known to be on a waiting list for renal transplantation, only 3.7% were receiving treatment. After restricting to HCV+ patients with overlapping propensity for antiviral treatment, 4 (9.5%) of 42 treated patients and 638 (21.0%) of 3,037 untreated patients died. The hazard ratio for adjusted mortality comparing treated patients with untreated patients was 0.47 (95% CI, 0.17-1.26). &lt;b&gt;&lt;i&gt;Conclusions:&lt;\/i&gt;&lt;\/b&gt; HD patients with hepatitis C infection very rarely receive antiviral therapy. Increased intervention might prolong survival for some patients and in particular might improve the prospects for those awaiting renal transplantation.<\/jats:p>","DOI":"10.1159\/000355615","type":"journal-article","created":{"date-parts":[[2013,10,29]],"date-time":"2013-10-29T04:45:38Z","timestamp":1383021938000},"page":"405-412","source":"Crossref","is-referenced-by-count":128,"title":["Hepatitis C Infection Is Very Rarely Treated among Hemodialysis Patients"],"prefix":"10.1159","volume":"38","author":[{"given":"David A.","family":"Goodkin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian","family":"Bieber","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brenda","family":"Gillespie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruce M.","family":"Robinson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michel","family":"Jadoul","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2013,10,29]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1755.2000.07413.x"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1053\/j.ajkd.2004.08.005"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1111\/j.1523-1755.2004.00649.x"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1755.1998.00883.x"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1016\/S0272-6386(98)70027-7"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/16.8.1669"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfn684"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1159\/000188520"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1053\/ajkd.2001.28590"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-6143.2010.03280.x"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1038\/ki.2008.81"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2007.133884"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1002\/hep.22545"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2893.2001.00300.xs"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1002\/hep.20119"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1002\/hep.22759"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1053\/j.ajkd.2007.11.003"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(99)06154-1"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfh895"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1111\/j.1523-1755.2005.00412.x"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1155\/2010\/267412"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-6143.2005.00864.x"}],"container-title":["American Journal of Nephrology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/355615","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/355615","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T14:10:58Z","timestamp":1745417458000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000355615"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013]]},"references-count":22,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2013,11,1]]},"published-print":{"date-parts":[[2013,11,27]]}},"URL":"https:\/\/doi.org\/10.1159\/000355615","archive":["Portico"],"relation":{},"ISSN":["0250-8095","1421-9670"],"issn-type":[{"value":"0250-8095","type":"print"},{"value":"1421-9670","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013]]}}}