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We retrospectively evaluated 19 patients affected by pITP resistant to 2 or more lines of therapy who were treated with rituximab. Nine of the 19 patients showed an initial response (47.4%). The sustained response rate was 31.6% (6\/19). The median follow-up of the patients was 53.2 months (range 9.2-92.9). Disease-free survival at 48 months was 62.2%. Following rituximab treatment, a proportion of patients (42%) recovered a normal B lymphocyte number. During the follow-up, no opportunistic or severe infectious complications were observed. These data confirm, over a long period of observation, the efficacy and safety of rituximab treatment in the management of patients with resistant pITP.<\/jats:p>","DOI":"10.1159\/000355650","type":"journal-article","created":{"date-parts":[[2013,12,19]],"date-time":"2013-12-19T09:22:37Z","timestamp":1387444957000},"page":"24-29","source":"Crossref","is-referenced-by-count":2,"title":["Rituximab in Previously Treated Primary Immune Thrombocytopenia Patients: Evaluation of Short- and Long-Term Efficacy and Safety"],"prefix":"10.1159","volume":"132","author":[{"given":"Cristina","family":"Santoro","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francesca","family":"Biondo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Erminia","family":"Baldacci","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria Stefania","family":"De Propris","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna","family":"Guarini","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francesca","family":"Paoloni","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roberto","family":"Fo\u00e0","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria Gabriella","family":"Mazzucconi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2013,12,19]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2009-07-229815"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2012-09-455691"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2011-08-374777"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2009-06-225565"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2010-08-302984"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-146-1-200701020-00006"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0609.2010.01486.x"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2008-01-131029"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2011-11-393975"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2008-07-162503"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V98.4.952"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.2004.04889.x"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1007\/s00277-005-0073-1"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.20276"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1016\/j.exphem.2006.02.009"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1007\/s11239-008-0208-z"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1007\/s12185-010-0635-4"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1007\/s00277-007-0317-3"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1097\/MOH.0b013e3282c8ca50"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1002\/hep.21051"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2008-10-186999"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0609.2002.02686.x"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.12206"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.12241"}],"container-title":["Acta Haematologica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/355650","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/355650","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/355650","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T18:11:13Z","timestamp":1745431873000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000355650"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,12,19]]},"references-count":24,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2014,6,1]]},"published-print":{"date-parts":[[2014,6,27]]}},"URL":"https:\/\/doi.org\/10.1159\/000355650","archive":["Portico"],"relation":{},"ISSN":["0001-5792","1421-9662"],"issn-type":[{"type":"print","value":"0001-5792"},{"type":"electronic","value":"1421-9662"}],"subject":[],"published":{"date-parts":[[2013,12,19]]}}}