{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T13:59:59Z","timestamp":1780581599103,"version":"3.54.1"},"reference-count":23,"publisher":"S. Karger AG","issue":"4","license":[{"start":{"date-parts":[[2013,1,1]],"date-time":"2013-01-01T00:00:00Z","timestamp":1356998400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2013,1,1]],"date-time":"2013-01-01T00:00:00Z","timestamp":1356998400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Dermatology"],"published-print":{"date-parts":[[2013]]},"abstract":"<b><i>Background:<\/i><\/b> In the treatment of atopic dermatitis, pimecrolimus has high antipruritic effects. <b><i>Objective:<\/i><\/b> To investigate the efficacy of 1% pimecrolimus cream in comparison to 1% hydrocortisone cream in non-atopic prurigo nodularis (PN). <b><i>Methods:<\/i><\/b> A randomized, controlled, double-blind study with intraindividual randomization was done in 30 patients (17 females, 13 males; mean age 58.5 years) with PN. <b><i>Results:<\/i><\/b> Pruritus intensity decreased significantly (p < 0.001) on both treated sides as early as after 10 days of treatment; scratch lesions improved (p < 0.001). Quality of life as assessed by the Dermatology Life Quality Index improved significantly. However, a significant advantage of pimecrolimus over hydrocortisone was not found. <b><i>Conclusion:<\/i><\/b> The results suggest that the non-steroid pimecrolimus is an effective alternative for PN treatment.<\/jats:p>","DOI":"10.1159\/000355671","type":"journal-article","created":{"date-parts":[[2013,11,25]],"date-time":"2013-11-25T08:00:44Z","timestamp":1385366444000},"page":"353-360","source":"Crossref","is-referenced-by-count":56,"title":["Evaluation of the Antipruritic Effects of Topical Pimecrolimus in Non-Atopic Prurigo Nodularis: Results of a Randomized, Hydrocortisone-Controlled, Double-Blind Phase II Trial"],"prefix":"10.1159","volume":"227","author":[{"given":"Dorothee","family":"Siepmann","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tobias","family":"Lotts","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christine","family":"Blome","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthias","family":"Braeutigam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ngoc Quan","family":"Phan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Trude","family":"Butterfass-Bahloul","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthias","family":"Augustin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas A.","family":"Luger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sonja","family":"St\u00e4nder","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2013,11,23]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-3083.2012.04481.x"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdermsci.2009.02.002"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1007\/s00105-003-0521-6"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.2147\/tcrm.2006.2.2.213"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1016\/j.neures.2004.07.005"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2007.07813.x"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1067\/mjd.2001.110059"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.1992.tb00452.x"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2230.1994.tb01167.x"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1111\/j.1610-0387.2012.08005.x"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1159\/000331577"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1080\/00029157.2011.10404357"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-0960.2005.00187.x"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.3109\/09546630903386606"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0560.2009.01484.x"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2011.10306.x"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2005.10.033"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1097\/ACI.0b013e32834a41c2"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2133.2001.04134.x"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2010.09757.x"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.2011.02747.x"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.2340\/00015555-1265"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.2340\/00015555-1246"}],"container-title":["Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/355671","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/355671","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T18:11:20Z","timestamp":1745431880000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000355671"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013]]},"references-count":23,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2014,1,1]]},"published-print":{"date-parts":[[2014,1,7]]}},"URL":"https:\/\/doi.org\/10.1159\/000355671","archive":["Portico"],"relation":{},"ISSN":["1018-8665","1421-9832"],"issn-type":[{"value":"1018-8665","type":"print"},{"value":"1421-9832","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013]]}}}