{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,10]],"date-time":"2025-11-10T20:57:26Z","timestamp":1762808246987,"version":"3.40.4"},"reference-count":30,"publisher":"S. Karger AG","issue":"6","license":[{"start":{"date-parts":[[2013,1,1]],"date-time":"2013-01-01T00:00:00Z","timestamp":1356998400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/3.0\/"},{"start":{"date-parts":[[2013,1,1]],"date-time":"2013-01-01T00:00:00Z","timestamp":1356998400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Kidney Blood Press Res"],"published-print":{"date-parts":[[2013]]},"abstract":"<jats:p>&lt;b&gt;&lt;i&gt;Background\/Aims: &lt;\/i&gt;&lt;\/b&gt;The aim of the study is to search for associations between Antineutrophil cytoplasm antibody (ANCA)-associated vasculitis (AAV) and polymorphisms in the genes of four key molecules possibly involved in different pathogenic pathways; complement C3, CTLA-4, Fc&amp;#947;-RIIa and IL1-Ra. &lt;b&gt;&lt;i&gt;Patients and Methods:&lt;\/i&gt;&lt;\/b&gt; Patients with AAV (n=105) subgrouped as microscopic polyangiitis or granulomatosis with polyangiitis (Wegener's granulomatosis) and myeloperoxidase (MPO) or proteinase 3 (PR3) ANCA positive were compared to a control group of 200 blood donors. Polymorphisms in the genes were analysed with PCR amplification of DNA. &lt;b&gt;&lt;i&gt;Results:&lt;\/i&gt;&lt;\/b&gt; The diagnosis of AAV was confirmed in the 105 cases. The gene frequency of C3F was 0.27 in the PR3-ANCA subgroup (p=0.041) compared to 0,19 in the control group. The number of patients homozygous for the shortest 86 bp allele of CTLA-4 was significantly decreased in the whole group of patients (p=0.049). No differences were evident in the Fc&amp;#947;-RIIa and IL1-Ra polymorphisms when compared to controls, neither in the whole group of patients, nor in any of the sub-groups. &lt;b&gt;&lt;i&gt;Conclusion: &lt;\/i&gt;&lt;\/b&gt;The aberrant gene frequency of the C3F allele among PR3-ANCA positive patients and the findings with the CTLA-4 polymorphism indicates that complement may be involved in pathogenesis and that T-cell activation also is of importance in these diseases.<\/jats:p>","DOI":"10.1159\/000355744","type":"journal-article","created":{"date-parts":[[2013,12,16]],"date-time":"2013-12-16T07:36:50Z","timestamp":1387179410000},"page":"641-648","source":"Crossref","is-referenced-by-count":17,"title":["A Candidate Gene Approach to ANCA-Associated Vasculitis Reveals Links to the C3 and CTLA-4 Genes but not to the IL1-Ra And Fc&amp;#947;-RIIa Genes"],"prefix":"10.1159","volume":"37","author":[{"given":"Ulf","family":"Persson","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Birgitta","family":"Gullstrand","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"\u00c5sa","family":"Pettersson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gunnar","family":"Sturfelt","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lennart","family":"Truedsson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M\u00e5rten","family":"Segelmark","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2013,12,14]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1189\/jlb.1202611"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.2353\/ajpath.2007.060573"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.0900173"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-120-1-199401010-00003"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1038\/nm968"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1038\/nm.1874"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1002\/art.23157"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1186\/ar2928"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1038\/ki.1995.360"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2350-10-12"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1002\/art.21487"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/ker446"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1108735"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1084\/jem.172.4.1011"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1007\/s002510050426"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1521-4141(199808)28:08<2598::AID-IMMU2598>3.0.CO;2-K"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2249.1999.00889.x"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2006.054593"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2362.1992.tb01447.x"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-5728(98)00119-2"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1210\/jc.80.1.41"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780370917"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1038\/ki.2012.313"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2249.1993.tb05917.x"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1034\/j.1399-3038.2001.012003166.x"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa072618"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2249.2001.01575.x"},{"key":"ref28","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa035075"},{"key":"ref29","doi-asserted-by":"publisher","DOI":"10.1007\/s11033-011-0741-2"},{"key":"ref30","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-5728(00)00191-0"}],"container-title":["Kidney and Blood Pressure Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/355744","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/355744","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/355744","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T18:12:26Z","timestamp":1745431946000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000355744"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013]]},"references-count":30,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2013,12,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000355744","archive":["Portico"],"relation":{},"ISSN":["1420-4096","1423-0143"],"issn-type":[{"type":"print","value":"1420-4096"},{"type":"electronic","value":"1423-0143"}],"subject":[],"published":{"date-parts":[[2013]]}}}