{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T22:32:28Z","timestamp":1792276348073,"version":"4.4.0"},"reference-count":24,"publisher":"S. Karger AG","issue":"1","license":[{"start":{"date-parts":[[2014,1,1]],"date-time":"2014-01-01T00:00:00Z","timestamp":1388534400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/3.0\/"},{"start":{"date-parts":[[2014,1,1]],"date-time":"2014-01-01T00:00:00Z","timestamp":1388534400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Kidney Blood Press Res"],"published-print":{"date-parts":[[2014]]},"abstract":"<jats:p>&lt;b&gt;&lt;i&gt;Background\/Aims: &lt;\/i&gt;&lt;\/b&gt;Cryoglobulinemic vasculitis remains an uncommon complication of hepatitis B virus infection. &lt;b&gt;&lt;i&gt;Methods: &lt;\/i&gt;&lt;\/b&gt;We report the case of a 40-years old female Chinese patient with chronic hepatitis B developing cryoglobulinemic vasculitis with multiple organ involvement (liver, kidney, and skin) coupled with weakness, arthralgias, haemolytic anaemia, and autoimmune thyroiditis. She received entecavir mono-therapy at dose adjusted for estimated glomerular filtration rate. &lt;b&gt;&lt;i&gt;Results: &lt;\/i&gt;&lt;\/b&gt;Within five months of entecavir treatment, hepatitis B viraemia decreased below the limit of detection with normal serum amino-transferase levels, HBeAg clearance occurred, vasculitis regressed with disappearance of purpura and ascites; in addition, renal function normalized and nephritic syndrome remitted. After a five-year follow-up, the patient is asymptomatic with intact kidney function, proteinuria in the normal range, and normal liver biochemistry, despite the antiviral treatment was withdrawn and the patient remained HBsAg positive. &lt;b&gt;&lt;i&gt;Conclusions: &lt;\/i&gt;&lt;\/b&gt;This is the second case of hepatitis B virus-related cryoglobulinemic vasculitis successfully treated with entecavir suggesting that effective antiviral therapy may counteract both the hepatic and extra-hepatic manifestations of infection by hepatitis B virus.<\/jats:p>","DOI":"10.1159\/000355778","type":"journal-article","created":{"date-parts":[[2014,7,10]],"date-time":"2014-07-10T06:48:39Z","timestamp":1404974919000},"page":"65-73","source":"Crossref","is-referenced-by-count":22,"title":["HBV-Associated Cryoglobulinemic Vasculitis: Remission after Antiviral Therapy with Entecavir"],"prefix":"10.1159","volume":"39","author":[{"given":"Mauro","family":"Vigan\u00f2","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul","family":"Martin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mattia","family":"Cappelletti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabrizio","family":"Fabrizi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2014,6,23]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2008.10.001"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2005.05.029"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1016\/j.dld.2006.12.017"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/40.9.1064"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1097\/00004836-200305000-00020"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-140-8-200404200-00035"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.2169\/internalmedicine.45.1816"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-149-12-200812160-00019"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcv.2012.10.014"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.2169\/internalmedicine.53.1203"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2010-3137"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1053\/j.ajkd.2012.08.040"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1159\/000324652"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinre.2012.03.033"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.1890440404"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1186\/1752-1947-6-39"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1016\/j.semarthrit.2003.10.001"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM197706302962605"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1016\/0140-6736(91)91478-D"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(80)90390-3"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1159\/000319696"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdq583"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-150-9-200905050-00023"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.25253"}],"container-title":["Kidney and Blood Pressure Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/355778","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/355778","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/355778","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T18:12:46Z","timestamp":1745431966000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000355778"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014]]},"references-count":24,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2014,7,1]]},"published-print":{"date-parts":[[2014,7,17]]}},"URL":"https:\/\/doi.org\/10.1159\/000355778","archive":["Portico"],"relation":{},"ISSN":["1420-4096","1423-0143"],"issn-type":[{"value":"1420-4096","type":"print"},{"value":"1423-0143","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014]]}}}