{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T09:05:40Z","timestamp":1792659940113,"version":"4.5.0"},"reference-count":35,"publisher":"S. Karger AG","issue":"1","license":[{"start":{"date-parts":[[2013,12,21]],"date-time":"2013-12-21T00:00:00Z","timestamp":1387584000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2013,12,21]],"date-time":"2013-12-21T00:00:00Z","timestamp":1387584000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Oncology"],"published-print":{"date-parts":[[2014]]},"abstract":"<jats:p>&lt;b&gt;&lt;i&gt;Objective:&lt;\/i&gt;&lt;\/b&gt; To analyze the clinical efficacy of &lt;sup&gt;90&lt;\/sup&gt;Y radioembolization in liver metastases from pancreatic cancer, to describe treatment toxicities and to identify biomarkers as predictors of outcome. &lt;b&gt;&lt;i&gt;Methods:&lt;\/i&gt;&lt;\/b&gt; Data from 19 pancreatic cancer patients (9 females\/10 males) who had received &lt;sup&gt;90&lt;\/sup&gt;Y radioembolization for metastatic liver disease between 06\/2004 and 01\/2011 were analyzed retrospectively. &lt;b&gt;&lt;i&gt;Results:&lt;\/i&gt;&lt;\/b&gt; The median age at &lt;sup&gt;90&lt;\/sup&gt;Y radioembolization was 63 years (range 43-77). In 16 patients, previous palliative gemcitabine-based chemotherapy was given for metastatic disease. Objective response in the liver after &lt;sup&gt;90&lt;\/sup&gt;Y radioembolization was 47%. Median local progression-free survival in the liver was 3.4 months (range 0.9-45.0). Median overall survival (OS) was 9.0 months (range 0.9-53.0) and 1-year survival was 24%. Cox regression models for baseline biomarkers at &lt;sup&gt;90&lt;\/sup&gt;Y radioembolization revealed correlations of increased carbohydrate antigen 19-9 (p = 0.02) and C-reactive protein (p = 0.03) with shorter OS. Short-term adverse events (nausea, vomiting, fatigue, fever and abdominal pain) did not exceed grade 3. As long-term adverse events, liver abscesses, gastroduodenal ulceration, cholestasis and cholangitis, ascites and spleen infarction were observed. &lt;b&gt;&lt;i&gt;Conclusion:&lt;\/i&gt;&lt;\/b&gt;&lt;sup&gt;90&lt;\/sup&gt;Y radioembolization is able to induce an encouraging local response rate of liver metastases of pancreatic cancer patients. Most short-term toxicities are manageable; however, patients should be followed up carefully for severe long-term toxicities.<\/jats:p>","DOI":"10.1159\/000355821","type":"journal-article","created":{"date-parts":[[2014,1,7]],"date-time":"2014-01-07T14:14:03Z","timestamp":1389104043000},"page":"24-32","source":"Crossref","is-referenced-by-count":44,"title":["Radioembolization with Yttrium-90 Microspheres (SIRT) in Pancreatic Cancer Patients with Liver Metastases: Efficacy, Safety and Prognostic 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