{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T19:25:46Z","timestamp":1787945146495,"version":"build-2784847793"},"reference-count":26,"publisher":"S. Karger AG","issue":"1-2","license":[{"start":{"date-parts":[[2013,10,25]],"date-time":"2013-10-25T00:00:00Z","timestamp":1382659200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2013,10,25]],"date-time":"2013-10-25T00:00:00Z","timestamp":1382659200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nephron Clin Pract"],"abstract":"<jats:p>&lt;b&gt;&lt;i&gt;Background:&lt;\/i&gt;&lt;\/b&gt; The aim of the study was to assess the relationship between fibroblast growth factor-23 (FGF-23) and vascular calcifications (VC) in peritoneal dialysis (PD) patients. &lt;b&gt;&lt;i&gt;Methods:&lt;\/i&gt;&lt;\/b&gt; A cross-sectional study was performed in 55 PD patients who underwent pelvic X-ray to assess for VC. Patients with and without linear calcifications were recorded. &lt;b&gt;&lt;i&gt;Results:&lt;\/i&gt;&lt;\/b&gt; Fifteen patients&lt;b&gt; &lt;\/b&gt;(27.3%) had linear calcifications on pelvic X-ray. FGF-23 levels were higher in patients with VC (299.5 (30.4-2,410.0) vs. 74.4 (14.8-1,030) pg\/ml, p &lt; 0.01). Diabetic patients had lower FGF-23 values (43.2 (14.9-134.0) vs. 103.5 (14.8-2,410) pg\/ml, p &lt; 0.01). Patients with residual renal function (RRF) had lower FGF-23 levels (70.6 (14.8-513) vs. 179.5 (30.4-2,410) pg\/ml, p = 0.06); however, this did not reach statistical significance. FGF-23 levels, age, creatinine, Ca, dialysis duration and HbA1c were positively correlated with VC, whereas RRF, Ca intake and ALP were negatively associated. Multivariate logistic analysis confirmed FGF-23 levels, age, dialysis duration and RRF to be associated with VC. &lt;b&gt;&lt;i&gt;Conclusions:&lt;\/i&gt;&lt;\/b&gt; FGF-23 levels are associated with VC in PD patients. Further studies are needed to clarify whether it is simply a marker or a potential factor. It may prove to be an important therapeutic target for VC management.<\/jats:p>","DOI":"10.1159\/000355859","type":"journal-article","created":{"date-parts":[[2013,10,25]],"date-time":"2013-10-25T11:10:25Z","timestamp":1382699425000},"page":"89-93","source":"Crossref","is-referenced-by-count":12,"title":["Fibroblast Growth Factor-23 Levels Are Associated with Vascular Calcifications in Peritoneal Dialysis Patients"],"prefix":"10.1159","volume":"124","author":[{"given":"Ebru","family":"Asicioglu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arzu","family":"Kahveci","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hakk\u0131","family":"Arikan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mehmet","family":"Koc","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Serhan","family":"Tuglular","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cetin Ishak","family":"Ozener","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2013,10,25]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1093%2Fndt%2Fgfh597"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1161%2Fhy1001.096358"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.2215%2FCJN.04800709"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1093%2Fndt%2Fgfn571"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1038%2Fki.2009.405"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1007%2Fs00431-010-1382-5"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1093%2Fndt%2Fgfq089"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1007%2Fs00198-006-0154-6"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1161%2FCIRCULATIONAHA.108.844506"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1007%2Fs00467-011-1822-0"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1159%2F000334424"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.2215%2FCJN.02160212"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.5301%2FJN.2010.5818"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1038%2Fnrendo.2009.196"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1681%2FASN.2009121311"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1161%2FCIRCULATIONAHA.111.053405"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1007%2Fs11255-008-9462-4"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.bone.2009.07.016"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.bone.2012.02.634"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1365-2265.2011.04299.x"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1093%2Fndt%2Fgfr596"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.2215%2FCJN.04290511"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1038%2Fsj.ki.5001820"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1093%2Fndt%2Fgfh217"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1093%2Fndt%2Fgfn584"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.1093%2Fndt%2Fgfg414"}],"container-title":["Nephron Clinical Practice"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/355859","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/355859","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T18:13:15Z","timestamp":1745431995000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000355859"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,10,25]]},"references-count":26,"journal-issue":{"issue":"1-2","published-online":{"date-parts":[[2013,12,1]]},"published-print":{"date-parts":[[2013,12,4]]}},"URL":"https:\/\/doi.org\/10.1159\/000355859","archive":["Portico"],"relation":{},"ISSN":["1660-2110"],"issn-type":[{"value":"1660-2110","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,10,25]]}}}