{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,18]],"date-time":"2026-01-18T21:16:13Z","timestamp":1768770973929,"version":"3.49.0"},"reference-count":56,"publisher":"S. Karger AG","issue":"1","license":[{"start":{"date-parts":[[2013,11,20]],"date-time":"2013-11-20T00:00:00Z","timestamp":1384905600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2013,11,20]],"date-time":"2013-11-20T00:00:00Z","timestamp":1384905600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neuroimmunomodulation"],"published-print":{"date-parts":[[2014]]},"abstract":"<jats:p>&lt;b&gt;&lt;i&gt;Objective(s):&lt;\/i&gt;&lt;\/b&gt; Peripheral stimulation of the innate immune system with lipopolysaccharide (LPS) causes prolonged depressive-like behavior in aged mice that is dependent on indoleamine 2,3 dioxygenase (IDO) activation. Regular moderate-intensity exercise training has been shown to exert neuroprotective effects that might reduce depressive-like behavior in aged mice. The purpose of this study was to test the hypothesis that voluntary wheel running (VWR) would attenuate LPS-induced depressive-like behavior and brain IDO gene expression in 4- and 22-month-old C57BL\/6J mice. &lt;b&gt;&lt;i&gt;Methods:&lt;\/i&gt;&lt;\/b&gt; Mice were housed with a running wheel (VWR) or no wheel (standard) for 30 (young adult mice) or 70 days (aged mice), after which they were intraperitoneally injected with LPS (young adult mice: 0.83 mg\/kg; aged mice: 0.33 mg\/kg).&lt;b&gt;&lt;i&gt; Results:&lt;\/i&gt;&lt;\/b&gt; Young adult VWR mice ran on average 6.9 km\/day, while aged VWR mice ran on average 3.4 km\/day. Both young adult and aged VWR mice increased their forced exercise tolerance compared to their respective standard control groups. VWR had no effect on LPS-induced anorexia, weight loss, increased immobility in the tail suspension test and decreased sucrose preference in either young adult or aged mice. Four (young adult mice) and 24 h (aged mice) after injection of LPS, mRNA transcripts for TNF-\u03b1, IL-1\u03b2, IL-6, and IDO were upregulated in the whole brain independently of VWR. &lt;b&gt;&lt;i&gt;Conclusion:&lt;\/i&gt;&lt;\/b&gt; Prolonged physical exercise has no effect on the neuroinflammatory response to LPS and its behavioral consequences in young adult and aged mice.<\/jats:p>","DOI":"10.1159\/000356144","type":"journal-article","created":{"date-parts":[[2013,11,20]],"date-time":"2013-11-20T13:12:25Z","timestamp":1384953145000},"page":"52-63","source":"Crossref","is-referenced-by-count":27,"title":["Voluntary Wheel Running Does Not Affect Lipopolysaccharide-Induced Depressive-Like Behavior in Young Adult and Aged Mice"],"prefix":"10.1159","volume":"21","author":[{"given":"Stephen 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