{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T14:18:49Z","timestamp":1790691529128,"version":"4.1.0"},"reference-count":24,"publisher":"S. Karger AG","issue":"2","license":[{"start":{"date-parts":[[2014,1,1]],"date-time":"2014-01-01T00:00:00Z","timestamp":1388534400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2014,1,1]],"date-time":"2014-01-01T00:00:00Z","timestamp":1388534400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Digestion"],"published-print":{"date-parts":[[2014]]},"abstract":"<jats:p>&lt;b&gt;&lt;i&gt;Background\/Aims:&lt;\/i&gt;&lt;\/b&gt; The intestinal pathophysiology in irritable bowel syndrome (IBS) is largely unknown. The lactulose breath test has been used to identify small bowel bacterial overgrowth in these patients. &lt;b&gt;&lt;i&gt;Methods:&lt;\/i&gt;&lt;\/b&gt; We studied intestinal transit in patients with IBS using of the SmartPill\u00ae (SP) wireless pH\/pressure recording capsule and performed lactulose breath tests to look for physiologic abnormalities. &lt;b&gt;&lt;i&gt;Results:&lt;\/i&gt;&lt;\/b&gt; A total of 35\/46 (76%) of the IBS patients had prolonged gastric emptying times. Constipation-predominant disease was associated with prolonged gut transit times. The mean hours \u00b1 SD for colonic transit time in the constipation group was 71.7 \u00b1 61.1 (n = 13) compared with 22.5 \u00b1 14.9 (n = 14) for diarrhea-predominant and 26.4 \u00b1 21.5 (n = 20) for mixed clinical subtype (p = 0.0010). No correlation between small bowel transit time and abnormal breath hydrogen or methane excretion in the 46 combined patients with IBS was seen. &lt;b&gt;&lt;i&gt;Conclusions:&lt;\/i&gt;&lt;\/b&gt; Delayed gastric emptying was identified in IBS and in some patients may contribute to at least a component of their symptoms. Constipation-predominant IBS is associated with prolonged gut transit times. Otherwise, transit abnormalities do not appear to be important in IBS. Intestinal transit did not correlate with breath test results.<\/jats:p>","DOI":"10.1159\/000356314","type":"journal-article","created":{"date-parts":[[2014,2,6]],"date-time":"2014-02-06T08:04:35Z","timestamp":1391673875000},"page":"119-123","source":"Crossref","is-referenced-by-count":47,"title":["Motility Abnormalities in Irritable Bowel Syndrome"],"prefix":"10.1159","volume":"89","author":[{"given":"Andrew W.","family":"DuPont","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhi-Dong","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen A.","family":"Harold","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ned","family":"Snyder","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Greg W.","family":"Galler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francisco","family":"Garcia-Torres","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Herbert L.","family":"DuPont","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2014,2,6]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2003.07542.x"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1007\/s10620-009-0899-9"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.00136.2009"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1111\/apt.12325"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1177\/1756283X12437874"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1017\/S0007114510004988"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1016\/j.appet.2011.03.006"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1053\/gast.2002.37095"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.2007.03564.x"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1007\/s12664-010-0015-2"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2012.5"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1136\/gut.36.4.585"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1001\/jama.292.7.852"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1007\/s10620-010-1276-4"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2010.05.017"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2005.11.046"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1089\/dia.2011.0078"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2003.07234.x"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1023\/A:1021738515885"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2008.01785.x"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2009.205476"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.2011.04625.x"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1007\/s10620-012-2033-7"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1007\/s10620-011-1700-4"}],"container-title":["Digestion"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/356314","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/356314","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/356314","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T18:16:42Z","timestamp":1745432202000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000356314"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014]]},"references-count":24,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2014,3,1]]},"published-print":{"date-parts":[[2014,3,12]]}},"URL":"https:\/\/doi.org\/10.1159\/000356314","archive":["Portico"],"relation":{},"ISSN":["0012-2823","1421-9867"],"issn-type":[{"value":"0012-2823","type":"print"},{"value":"1421-9867","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014]]}}}