{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,20]],"date-time":"2026-03-20T19:09:29Z","timestamp":1774033769019,"version":"3.50.1"},"reference-count":18,"publisher":"S. Karger AG","issue":"5-6","license":[{"start":{"date-parts":[[2013,1,1]],"date-time":"2013-01-01T00:00:00Z","timestamp":1356998400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2013,1,1]],"date-time":"2013-01-01T00:00:00Z","timestamp":1356998400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pharmacology"],"published-print":{"date-parts":[[2013]]},"abstract":"<b><i>Aims:<\/i><\/b> Recent studies have reported that intracellular calcium (Ca<sup>2+<\/sup>) mobilization is involved in homocysteine (Hcy)-induced endothelial dysfunction and the Na<sup>+<\/sup>\/H<sup>+<\/sup> exchanger (NHE) is responsible for an increase in the intracellular Ca<sup>2+<\/sup> concentration in cardiovascular disease. We hypothesized that inhibition of the NHE had protective effects on Hcy-induced endothelial dysfunction. <b><i>Methods:<\/i><\/b> Acetylcholine-induced endothelium-dependent relaxation (EDR) and biochemical parameters were measured in the rat isolated aorta. The level of reactive oxygen species (ROS) was designed by a specific fluorescent probe. The phosphorylation of the nuclear factor-&#954;B (NF-&#954;B) system was studied by Western blot. <b><i>Results:<\/i><\/b> Cariporide significantly prevented Hcy-impaired EDR and increased nitric oxide (NO) release; endothelial NO synthase activity simultaneously decreased ROS production. We also found that cariporide blocked Hcy-induced NF-&#954;B activation and inhibitor-&#954;B degradation, thus inhibiting the production of tumor necrosis factor-a and intercellular adhesion molecule-1. <b><i>Conclusions:<\/i><\/b> The mechanisms of protective effects of cariporide may be related to the inhibition of NHE and the decrease in oxidative stress and inflammatory injury.<\/jats:p>","DOI":"10.1159\/000356318","type":"journal-article","created":{"date-parts":[[2013,12,2]],"date-time":"2013-12-02T12:02:25Z","timestamp":1385985745000},"page":"303-309","source":"Crossref","is-referenced-by-count":11,"title":["Protective Effects of Cariporide on Endothelial Dysfunction Induced by Homocysteine"],"prefix":"10.1159","volume":"92","author":[{"given":"Shujin","family":"Wu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiang","family":"Gao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shehua","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liying","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bin","family":"Ge","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qingshan","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2013,11,30]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1053\/j.ajkd.2009.01.266"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9343(02)01021-5"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.2174\/187152910793743887"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1016\/S0753-3322(01)00125-1"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2004.03.019"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1016\/S0167-4889(01)00130-6"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1517\/13543784.2010.532123"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1016\/j.ydbio.2012.02.010"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1016\/j.vph.2012.11.004"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1097\/01.fjc.0000161401.14327.38"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/cvn179"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1111\/j.1582-4934.2008.00200.x"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.3109\/13813455.2011.635660"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1111\/j.1745-7254.2005.00042.x"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1006\/jsre.2001.6304"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1159\/000346128"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.00491.2001"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.101.23.2749"}],"container-title":["Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/356318","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/356318","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T18:16:44Z","timestamp":1745432204000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000356318"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013]]},"references-count":18,"journal-issue":{"issue":"5-6","published-online":{"date-parts":[[2014,1,1]]},"published-print":{"date-parts":[[2014,1,9]]}},"URL":"https:\/\/doi.org\/10.1159\/000356318","archive":["Portico"],"relation":{},"ISSN":["0031-7012","1423-0313"],"issn-type":[{"value":"0031-7012","type":"print"},{"value":"1423-0313","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013]]}}}