{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,11]],"date-time":"2026-01-11T09:28:27Z","timestamp":1768123707235,"version":"3.49.0"},"reference-count":17,"publisher":"S. Karger AG","issue":"2","license":[{"start":{"date-parts":[[2013,12,10]],"date-time":"2013-12-10T00:00:00Z","timestamp":1386633600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"},{"start":{"date-parts":[[2013,12,10]],"date-time":"2013-12-10T00:00:00Z","timestamp":1386633600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Dermatology"],"published-print":{"date-parts":[[2014]]},"abstract":"<jats:p>Background: The role of single-nucleotide polymorphisms (SNPs) of the TNF gene in acne vulgaris remains controversial. Methods: Genomic DNA was isolated from 185 patients with acne vulgaris and 165 healthy controls. SNPs at positions -376, -308 and -238 of the promoter region of TNF were defined. Results: The frequency of the GAG haplotype was greater among patients (16.8%) than among controls with borderline significance (9.7%, p = 0.059). Male carriers of haplotypes other than GGG presented acne vulgaris at a later age than carriers of the GGG haplotype. No effect of the GAG haplotype on the frequency of acne conglobata was found among women with polycystic ovary syndrome. Conclusions: Carriage of the GAG haplotype of TNF is linked with borderline susceptibility to acne vulgaris. The GGG haplotype is related with earlier disease onset in male patients.<\/jats:p>","DOI":"10.1159\/000356388","type":"journal-article","created":{"date-parts":[[2013,12,10]],"date-time":"2013-12-10T07:39:01Z","timestamp":1386661141000},"page":"152-157","source":"Crossref","is-referenced-by-count":16,"title":["Impact of TNF Haplotypes in the Physical Course of Acne Vulgaris"],"prefix":"10.1159","volume":"228","author":[{"given":"Ioanna","family":"Grech","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sophia","family":"Giatrakos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Georgia","family":"Damoraki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Philippos","family":"Kaldrimidis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dimitrios","family":"Rigopoulos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Evangelos J.","family":"Giamarellos-Bourboulis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2013,12,10]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-3083.2010.03919.x"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1016\/j.humimm.2011.05.012"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-3083.2008.02891.x"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-0039.2010.01530.x"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-3083.2011.04338.x"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1007\/s00403-008-0871-0"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1007\/s00403-010-1050-7"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-3083.2008.02858.x"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1159\/000067818"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1016\/j.cyto.2012.04.040"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1097\/CCM.0b013e3181b42af0"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1016\/j.cyto.2011.04.012"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1016\/j.clindermatol.2004.03.012"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1016\/j.cyto.2003.12.003"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijid.2011.11.012"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1159\/000119108"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1210\/jcem.86.8.7770"}],"container-title":["Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/karger.com\/drm\/article-pdf\/228\/2\/152\/3893919\/000356388.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/karger.com\/drm\/article-pdf\/228\/2\/152\/3893919\/000356388.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T18:17:53Z","timestamp":1745432273000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000356388"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,12,10]]},"references-count":17,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2014,3,1]]},"published-print":{"date-parts":[[2014,3,25]]}},"URL":"https:\/\/doi.org\/10.1159\/000356388","archive":["Portico"],"relation":{"is-supplemented-by":[{"id-type":"doi","id":"10.6084\/m9.figshare.5125828","asserted-by":"subject"}]},"ISSN":["1018-8665","1421-9832"],"issn-type":[{"value":"1018-8665","type":"print"},{"value":"1421-9832","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,12,10]]}}}