{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,25]],"date-time":"2025-10-25T12:13:34Z","timestamp":1761394414547,"version":"3.40.4"},"reference-count":30,"publisher":"S. Karger AG","issue":"1","license":[{"start":{"date-parts":[[2013,12,7]],"date-time":"2013-12-07T00:00:00Z","timestamp":1386374400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2013,12,7]],"date-time":"2013-12-07T00:00:00Z","timestamp":1386374400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acta Cytologica"],"published-print":{"date-parts":[[2014]]},"abstract":"<jats:p>&lt;b&gt;&lt;i&gt;Objective:&lt;\/i&gt;&lt;\/b&gt; It was the aim of this study to determine the utility of PAX2 and PAX8 in cytology effusions with metastatic tumor. &lt;b&gt;&lt;i&gt;Study Design:&lt;\/i&gt;&lt;\/b&gt; PAX2 and PAX8 immunohistochemical staining was performed on cell blocks of 89 pleural, pericardial and peritoneal effusions with benign diagnoses (18 cases), or secondary to renal cell carcinoma (RCC; 9 cases), m\u00fcllerian carcinoma (21 cases) or non-m\u00fcllerian carcinoma (41 cases). &lt;b&gt;&lt;i&gt;Results:&lt;\/i&gt;&lt;\/b&gt; PAX2 stained 0% (0\/18) of controls, 100% (8\/8) of RCCs, 35% (7\/20) of m\u00fcllerian carcinomas, and 2% (1\/41) of non-m\u00fcllerian carcinomas. PAX8 stained 6% (1\/18) of control cases, 100% (9\/9) of RCC cases, 100% (20\/20) of m\u00fcllerian carcinomas, and 5% (2\/41) of non-m\u00fcllerian carcinomas. PAX2 was 35% sensitive and 95% specific for m\u00fcllerian carcinoma and 100% sensitive and 95% specific for RCC. PAX8 was 100% sensitive and 95% specific for m\u00fcllerian carcinoma and 100% sensitive and 95% specific for RCC. &lt;b&gt;&lt;i&gt;Conclusions:&lt;\/i&gt;&lt;\/b&gt; PAX8 is more sensitive than PAX2 for metastatic effusions from m\u00fcllerian carcinomas (100 vs. 35%), while also having a higher intensity of staining than PAX2. However, PAX2 and PAX8 are both highly sensitive and specific for RCCs. PAX2 and PAX8 are valuable diagnostic markers for metastatic m\u00fcllerian carcinomas and RCCs in effusion cytology. 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