{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T01:38:40Z","timestamp":1791855520825,"version":"4.3.4"},"reference-count":32,"publisher":"S. Karger AG","issue":"6","license":[{"start":{"date-parts":[[2013,1,1]],"date-time":"2013-01-01T00:00:00Z","timestamp":1356998400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2013,1,1]],"date-time":"2013-01-01T00:00:00Z","timestamp":1356998400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Am J Nephrol"],"published-print":{"date-parts":[[2013]]},"abstract":"<jats:p>&lt;b&gt;&lt;i&gt;Background:&lt;\/i&gt;&lt;\/b&gt; Though rituximab (RTX) is effective for childhood steroid-dependent nephrotic syndrome (SDNS), an established regimen does not exist. The relapses tend to occur when the peripheral blood B-cell count re-arises at 3 months upon single RTX infusion. This study was conducted to clarify whether the long-term remission of SDNS can be obtained by repeated RTX administrations. &lt;b&gt;&lt;i&gt;Methods:&lt;\/i&gt;&lt;\/b&gt; RTX was administered 4 times at 3-month intervals at 375 mg\/m&lt;sup&gt;2&lt;\/sup&gt;\/time to 5 children with SDNS. The changes in the clinical indicators were analyzed. &lt;b&gt;&lt;i&gt;Results:&lt;\/i&gt;&lt;\/b&gt; The median (range) observation period was 6.3 (0.9-8.4) years before RTX and 3.2 (1.9-3.8) years following the commencement of RTX. The changes in the clinical indicators were as follows (median and range): (1) annual number of relapses: before administration 1.4 (1.1-3.5) times\/year, after administration 0.0 (0.0-0.0) times\/year, and (2) median steroid dosage: before administration 0.80 (0.23-0.96) mg\/kg\/day, after administration 0.00 (0.00-0.00) mg\/kg\/day. All changes were significant at p &lt; 0.05. Relapse occurred 3 times following the start of RTX (the period to relapse was 2.2, 1.9, and 2.3 years, respectively). No serious side effects were seen. &lt;b&gt;&lt;i&gt;Conclusions:&lt;\/i&gt;&lt;\/b&gt; Repeated RTX against SDNS in children may be a useful therapeutic option.<\/jats:p>","DOI":"10.1159\/000356439","type":"journal-article","created":{"date-parts":[[2013,12,2]],"date-time":"2013-12-02T12:02:25Z","timestamp":1385985745000},"page":"483-488","source":"Crossref","is-referenced-by-count":23,"title":["Novel Use of Rituximab for Steroid-Dependent Nephrotic Syndrome in 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