{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,27]],"date-time":"2026-05-27T17:39:06Z","timestamp":1779903546640,"version":"3.53.1"},"reference-count":14,"publisher":"S. Karger AG","issue":"2","license":[{"start":{"date-parts":[[2013,12,4]],"date-time":"2013-12-04T00:00:00Z","timestamp":1386115200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2013,12,4]],"date-time":"2013-12-04T00:00:00Z","timestamp":1386115200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int Arch Allergy Immunol"],"published-print":{"date-parts":[[2014]]},"abstract":"<jats:p>Recurrent, pulseless-electrical-activity (PEA) cardiac arrests were the novel presentation of untreated systemic mastocytosis in an 85-year-old woman who lacked cutaneous findings of mastocytosis. Despite prior implantation of a dual-chamber cardiac pacemaker 3 weeks previously for similar spells, she experienced a PEA arrest accompanied by flushing, increased urinary &lt;i&gt;N&lt;\/i&gt;-methylhistamine excretion and serum tryptase values on the day of presentation to our clinic. Bone marrow biopsy findings conducted to rule out breast cancer metastases showed 30% mast cell infiltration, aberrant expression of CD25 and a positive c-kit Asp816Val mutation. Treatment with a combination of H&lt;sub&gt;1&lt;\/sub&gt; and H&lt;sub&gt;2&lt;\/sub&gt; receptor blockers reduced flushing and eliminated hypotension. Maintenance medication included aspirin, cetirizine, ranitidine, montelukast, oral cromolyn sodium and an epinephrine autoinjector (as needed). At 6-month follow-up, the patient remained free of PEA arrests, flushing, or any clinical signs of mastocytosis or mast cell degranulation. PEA cardiac arrests may therefore be a presenting sign of untreated systemic mastocytosis.<\/jats:p>","DOI":"10.1159\/000356487","type":"journal-article","created":{"date-parts":[[2013,12,4]],"date-time":"2013-12-04T08:31:26Z","timestamp":1386145886000},"page":"130-134","source":"Crossref","is-referenced-by-count":4,"title":["Presentation of Untreated Systemic Mastocytosis as Recurrent, Pulseless-Electrical-Activity Cardiac Arrests Resistant to Cardiac Pacemaker"],"prefix":"10.1159","volume":"163","author":[{"given":"Joseph H.","family":"Butterfield","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catherine R.","family":"Weiler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2013,12,4]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.jaci.2009.11.017"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1002%2F0470861193.ch11"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1126%2Fscience.6701530"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1016%2F0024-3205%2880%2990209-X"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1159%2F000328760"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.iac.2006.05.005"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1097%2FCCM.0b013e318161f504"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1056%2FNEJMoa1200657"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.resuscitation.2005.06.012"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1067%2Fmai.2002.126811"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.resuscitation.2007.08.022"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1067%2Fmai.2003.1614"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1398-9995.2009.02118.x"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1159%2F000144042"}],"container-title":["International Archives of Allergy and Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/356487","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/356487","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T18:18:54Z","timestamp":1745432334000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000356487"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,12,4]]},"references-count":14,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2014,2,1]]},"published-print":{"date-parts":[[2014,2,6]]}},"URL":"https:\/\/doi.org\/10.1159\/000356487","archive":["Portico"],"relation":{},"ISSN":["1018-2438","1423-0097"],"issn-type":[{"value":"1018-2438","type":"print"},{"value":"1423-0097","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,12,4]]}}}