{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,5]],"date-time":"2026-09-05T05:56:58Z","timestamp":1788587818234,"version":"build-2803163510"},"reference-count":16,"publisher":"S. Karger AG","issue":"1","license":[{"start":{"date-parts":[[2014,1,1]],"date-time":"2014-01-01T00:00:00Z","timestamp":1388534400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2014,1,1]],"date-time":"2014-01-01T00:00:00Z","timestamp":1388534400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acta Haematol"],"published-print":{"date-parts":[[2014]]},"abstract":"<jats:p>&lt;b&gt;&lt;i&gt;Background\/Aims:&lt;\/i&gt;&lt;\/b&gt; There exists few pediatric data on the safety and efficacy of prophylactic antibiotics during chemotherapy-induced agranulocytosis. &lt;b&gt;&lt;i&gt;Methods:&lt;\/i&gt;&lt;\/b&gt; We prospectively studied the incidence of infection-related fever in 38 children, aged 2-16 years, with acute myeloid leukemia (AML) over 121 chemotherapy treatment cycles. A prophylactic group (n = 18) was given either vancomycin\/cefepime (400 mg\/m&lt;sup&gt;2&lt;\/sup&gt;, q12 h\/50 mg\/kg, q12 h) or piperacillin\/tazobactam (110 mg\/kg, q12 h). Control patients (n = 20) received no preventive antibiotics. &lt;b&gt;&lt;i&gt;Results:&lt;\/i&gt;&lt;\/b&gt; The prophylactic group (59 treatment cycles) experienced fever less frequently than the control group (0.4 vs. 0.9 events; p &lt; 0.001), had a longer interval between agranulocytosis and fever (6.4 vs. 3.8 days; p = 0.007), had a shorter duration of hospitalization (21.5 vs. 28.5 days; p &lt; 0.001), and had a lower rate of lung infection (38.8 vs. 80.0%; p &lt; 0.001). One patient taking vancomycin experienced a skin rash and 3 patients taking piperacillin\/tazobactam had diarrhea; these side effects subsided after antibiotics were discontinued. &lt;b&gt;&lt;i&gt;Conclusions:&lt;\/i&gt;&lt;\/b&gt; In children with AML, prophylactic antibiotics during the period of chemotherapy-induced agranulocytosis can effectively reduce the incidence of infectious fever and can shorten the average length of hospital stay, improving treatment success and quality of life.<\/jats:p>","DOI":"10.1159\/000356626","type":"journal-article","created":{"date-parts":[[2014,2,13]],"date-time":"2014-02-13T10:44:20Z","timestamp":1392288260000},"page":"112-117","source":"Crossref","is-referenced-by-count":19,"title":["Prophylactic First-Line Antibiotics Reduce Infectious Fever and Shorten Hospital Stay during Chemotherapy-Induced Agranulocytosis in Childhood Acute Myeloid Leukemia"],"prefix":"10.1159","volume":"132","author":[{"given":"Xiaoqin","family":"Feng","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongsheng","family":"Ruan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuelin","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuming","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuedong","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huayin","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuan","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lan","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunfu","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2014,2,12]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2012-03-416701"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2012-02-408336"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(10)70090-5"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1097\/01.inf.0000164708.21464.03"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1097\/00006454-198911000-00005"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.20382"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.2010.08389.x"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa044097"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-142-12_Part_1-200506210-00008"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/cir073"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2008.07.008"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-0691.2005.01114.x"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMc052613"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1007\/s10096-005-1278-x"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.23563"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.20065"}],"container-title":["Acta Haematologica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/356626","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/356626","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/356626","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T18:20:07Z","timestamp":1745432407000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000356626"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014]]},"references-count":16,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2014,6,1]]},"published-print":{"date-parts":[[2014,6,27]]}},"URL":"https:\/\/doi.org\/10.1159\/000356626","archive":["Portico"],"relation":{},"ISSN":["0001-5792","1421-9662"],"issn-type":[{"value":"0001-5792","type":"print"},{"value":"1421-9662","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014]]}}}