{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,5]],"date-time":"2025-10-05T17:01:39Z","timestamp":1759683699625,"version":"3.40.4"},"reference-count":11,"publisher":"S. Karger AG","issue":"2","license":[{"start":{"date-parts":[[2013,12,21]],"date-time":"2013-12-21T00:00:00Z","timestamp":1387584000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2013,12,21]],"date-time":"2013-12-21T00:00:00Z","timestamp":1387584000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Audiol Neurotol"],"published-print":{"date-parts":[[2014]]},"abstract":"<jats:p>&lt;b&gt;&lt;i&gt;Background:&lt;\/i&gt;&lt;\/b&gt; The present study investigated whether prochlorperazine affects vestibulo-ocular reflex (VOR) and vestibulo-perceptual function. &lt;b&gt;&lt;i&gt;Methods:&lt;\/i&gt;&lt;\/b&gt; We studied 12 healthy na\u00efve subjects 3 h after a single dose of oral prochlorperazine 5 mg in a randomised, placebo-controlled, double-blind, crossover study in healthy young subjects. Two rotational tests in yaw were used: (1) a threshold task investigating perceptual motion detection and nystagmic thresholds (acceleration steps of 0.5\u00b0\/s&lt;sup&gt;2&lt;\/sup&gt;) and (2) suprathreshold responses to velocity steps of 90\u00b0\/s in which vestibulo-ocular and vestibuloperceptual time constants of decay, as well as VOR gain, were measured. &lt;b&gt;&lt;i&gt;Results:&lt;\/i&gt;&lt;\/b&gt; Prochlorperazine had no effect upon any measure of nystagmic or perceptual vestibular function compared to placebo. This lack of effects on vestibular-mediated motion perception suggests that the drug is likely to act more as an anti-emetic than as an antivertiginous agent.<\/jats:p>","DOI":"10.1159\/000357028","type":"journal-article","created":{"date-parts":[[2013,12,20]],"date-time":"2013-12-20T10:06:37Z","timestamp":1387533997000},"page":"91-96","source":"Crossref","is-referenced-by-count":6,"title":["Effects of Prochlorperazine on Normal Vestibular Ocular and Perceptual Responses: A Randomised, Double-Blind, Crossover, Placebo-Controlled Study"],"prefix":"10.1159","volume":"19","author":[{"given":"M.","family":"Patel","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Y.","family":"Nigmatullina","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B.M.","family":"Seemungal","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.F.","family":"Golding","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.M.","family":"Bronstein","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2013,12,21]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1152\/jn.00154.2010"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1196\/annals.1303.034"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0061862"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1007\/BF01276416"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.2011.06159.x"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1007\/s00221-005-0264-y"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1097\/WNR.0b013e3283646e65"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/122.7.1293"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.2009.03855.x"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1007\/BF00236613"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1007\/s12311-012-0401-7"}],"container-title":["Audiology and Neurotology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/357028","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/357028","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T18:23:57Z","timestamp":1745432637000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000357028"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,12,21]]},"references-count":11,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2014,3,1]]},"published-print":{"date-parts":[[2014,3,20]]}},"URL":"https:\/\/doi.org\/10.1159\/000357028","archive":["Portico"],"relation":{},"ISSN":["1420-3030","1421-9700"],"issn-type":[{"type":"print","value":"1420-3030"},{"type":"electronic","value":"1421-9700"}],"subject":[],"published":{"date-parts":[[2013,12,21]]}}}