{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T19:15:31Z","timestamp":1793128531699,"version":"4.5.0"},"reference-count":10,"publisher":"S. Karger AG","issue":"1","license":[{"start":{"date-parts":[[2014,7,8]],"date-time":"2014-07-08T00:00:00Z","timestamp":1404777600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2014,7,8]],"date-time":"2014-07-08T00:00:00Z","timestamp":1404777600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acta Haematol"],"published-print":{"date-parts":[[2015]]},"abstract":"<jats:p>&lt;b&gt;&lt;i&gt;Background:&lt;\/i&gt;&lt;\/b&gt; The effect of vitamin D replacement on hemoglobin (Hb) concentration in subjects with concurrent deficiencies of vitamin D and iron is not known. &lt;b&gt;&lt;i&gt;Methods:&lt;\/i&gt;&lt;\/b&gt; We report on an investigator-initiated, randomized, single-blinded, placebo-controlled, 12-week interventional trial. Thirty subjects with iron-deficiency anemia (serum ferritin &lt;15 \u00b5g\/l) were randomized to an intervention arm (cholecalciferol, i.e. vitamin D&lt;sub&gt;3&lt;\/sub&gt;, 0.6 million units i.m. once) or placebo. In all subjects, iron deficiency was corrected with parental iron. Other causes of anemia were excluded with appropriate investigation. The primary end point was a rise in Hb concentration. &lt;b&gt;&lt;i&gt;Results:&lt;\/i&gt;&lt;\/b&gt; Baseline parameters of age, BMI, hemogram values and levels of serum ferritin, 25-hydroxyvitamin D [25(OH)D] and parathyroid hormone (PTH) were similar in the 2 arms. Twelve weeks after vitamin D replacement, there was a significant increase in 25 (OH)D levels (57.7 \u00b1 20.5 vs. 14.1 \u00b1 6.2 ng\/ml, p &lt; 0.0001) and a decrease in PTH levels (32.4 \u00b1 16.4 vs. 52.9 \u00b1 18.4 pg\/ml, p = 0.003) in subjects in the intervention arm when compared to the placebo arm. However, the increments in serum ferritin and Hb concentration in the intervention and placebo arm did not differ. &lt;b&gt;&lt;i&gt;Conclusion:&lt;\/i&gt;&lt;\/b&gt; Vitamin D replacement in subjects with iron-deficiency anemia after iron correction does not improve Hb concentration further.<\/jats:p>","DOI":"10.1159\/000357104","type":"journal-article","created":{"date-parts":[[2014,7,8]],"date-time":"2014-07-08T07:01:51Z","timestamp":1404802911000},"page":"31-35","source":"Crossref","is-referenced-by-count":25,"title":["Effect of Vitamin D Replacement on Hemoglobin Concentration in Subjects with Concurrent Iron-Deficiency Anemia and Vitamin D Deficiency: A Randomized, Single-Blinded, Placebo-Controlled Trial"],"prefix":"10.1159","volume":"133","author":[{"given":"Basavraj","family":"Sooragonda","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sanjay Kumar","family":"Bhadada","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Viral N.","family":"Shah","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pankaj","family":"Malhotra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jasmina","family":"Ahluwalia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naresh","family":"Sachdeva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2014,7,8]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1007\/s00198-004-1703-5"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1007\/s00198-003-1491-3"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.4158\/EP10155.OR"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1136\/adc.61.9.843"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.nu.11.070191.001201"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1016\/S0301-472X(02)00789-0"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1038\/ki.2009.551"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1159\/000074837"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199301213280304"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2265.2008.03346.x"}],"container-title":["Acta Haematologica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/357104","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/357104","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/357104","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T18:24:54Z","timestamp":1745432694000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000357104"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,7,8]]},"references-count":10,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2014,11,1]]},"published-print":{"date-parts":[[2014,12,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000357104","archive":["Portico"],"relation":{},"ISSN":["0001-5792","1421-9662"],"issn-type":[{"value":"0001-5792","type":"print"},{"value":"1421-9662","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,7,8]]}}}