{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,26]],"date-time":"2025-11-26T15:48:01Z","timestamp":1764172081044,"version":"3.40.4"},"reference-count":17,"publisher":"S. Karger AG","issue":"2","license":[{"start":{"date-parts":[[2014,1,1]],"date-time":"2014-01-01T00:00:00Z","timestamp":1388534400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2014,1,1]],"date-time":"2014-01-01T00:00:00Z","timestamp":1388534400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cytogenet Genome Res"],"published-print":{"date-parts":[[2014]]},"abstract":"<jats:p>Two fragile sites, FRA16B and FRA16C, are located in the chromosome band 16q22.1. Neither of them is associated with any specific clinical condition. We report the development and outcome of a clinically applied PGD cycle in a couple who had difficulty in achieving pregnancy. The woman was a carrier of a balanced reciprocal translocation, t(11;22)(q23;q11.2), and the man presented high expression of the fragile site 16q22.1 (FRA16B\/C) in peripheral blood lymphocytes. Gains and losses of chromosome 16 fragments were detected in sperm and embryos. To our knowledge, this is the first documented case suggesting a link between FRA16B\/C and chromosome 16 abnormalities in embryos and sperm from a carrier.<\/jats:p>","DOI":"10.1159\/000357411","type":"journal-article","created":{"date-parts":[[2014,1,20]],"date-time":"2014-01-20T09:39:23Z","timestamp":1390210763000},"page":"134-139","source":"Crossref","is-referenced-by-count":6,"title":["Chromosome 16 Abnormalities in Embryos and in Sperm from a Male with a Fragile Site at 16q22.1"],"prefix":"10.1159","volume":"142","author":[{"given":"M.R.","family":"Martorell","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"O.","family":"Mart\u00ednez-Pasarell","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"O.","family":"Lopez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Polo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Sandalinas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E.","family":"Garcia-Guix\u00e9","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L.","family":"Bassas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2014,1,14]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1447-0756.2012.01850.x"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00278996"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1159\/000086901"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkp1245"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddm136"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/17.1.233"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1159\/000072841"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbagrm.2007.10.005"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1136\/jmg.23.3.279"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1007\/BF00221948"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0223(199812)18:13<1459::AID-PD514>3.0.CO;2-V"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1530\/rep.1.01063"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1007\/BF00278788"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1007\/BF00272446"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1038\/ejhg.2010.166"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1093\/molehr\/5.7.682"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.23.20.7143-7151.2003"}],"container-title":["Cytogenetic and Genome Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/357411","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/357411","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T18:27:50Z","timestamp":1745432870000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000357411"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014]]},"references-count":17,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2014,2,1]]},"published-print":{"date-parts":[[2014,2,4]]}},"URL":"https:\/\/doi.org\/10.1159\/000357411","archive":["Portico"],"relation":{},"ISSN":["1424-8581","1424-859X"],"issn-type":[{"type":"print","value":"1424-8581"},{"type":"electronic","value":"1424-859X"}],"subject":[],"published":{"date-parts":[[2014]]}}}