{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,30]],"date-time":"2026-03-30T14:10:22Z","timestamp":1774879822927,"version":"3.50.1"},"reference-count":28,"publisher":"S. Karger AG","issue":"1","license":[{"start":{"date-parts":[[2014,1,1]],"date-time":"2014-01-01T00:00:00Z","timestamp":1388534400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2014,1,1]],"date-time":"2014-01-01T00:00:00Z","timestamp":1388534400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Fetal Diagn Ther"],"published-print":{"date-parts":[[2014]]},"abstract":"<jats:p>&lt;b&gt;&lt;i&gt;Objective:&lt;\/i&gt;&lt;\/b&gt; To investigate prenatal ultrasonographic findings associated with megacystis-microcolon-intestinal hypoperistalsis syndrome (MMIHS). &lt;b&gt;&lt;i&gt;Methods:&lt;\/i&gt;&lt;\/b&gt; A PubMed search was performed using the terms \u2018MMIHS', \u2018MMIH' and \u2018prenatal diagnosis'. &lt;b&gt;&lt;i&gt;Results:&lt;\/i&gt;&lt;\/b&gt; A total of 50 cases were analyzed. Prenatal diagnosis was achieved in 26% of cases. In 54% of patients with a correct antenatal diagnosis there was a previously affected sibling. Fetal megacystis with or without hydroureteronephrosis was the most common initial ultrasonographic finding (88%). While megacystis eventually complicated all fetal presentations, isolated bilateral hydronephrosis and isolated dilated stomach were noted (in 10 and 2% of cases, respectively) prior to megacystis. The initial sonographic abnormality was most commonly detected (in 70% of patients) in the second trimester. Amniotic fluid was normal in 69% and increased in 27% of cases. Gastrointestinal abnormalities were noted in 24% of pregnancies. &lt;b&gt;&lt;i&gt;Conclusion:&lt;\/i&gt;&lt;\/b&gt; MMIHS should be prenatally suspected when fetal megacystis is associated with a normal or increased amount of amniotic fluid and normal external genitalia, especially in the setting of a suggestive family history. Associated gastrointestinal findings support this diagnosis. Isolated bilateral hydronephrosis may precede the development of megacystis. Due to preserved renal function and a general absence of oligohydramnios, no rationale exists for vesicoamniotic shunt placement.<\/jats:p>","DOI":"10.1159\/000357703","type":"journal-article","created":{"date-parts":[[2014,12,8]],"date-time":"2014-12-08T15:04:18Z","timestamp":1418051058000},"page":"74-80","source":"Crossref","is-referenced-by-count":36,"title":["Megacystis-Microcolon-Intestinal Hypoperistalsis Syndrome: Case Report and Review of Prenatal Ultrasonographic Findings"],"prefix":"10.1159","volume":"36","author":[{"given":"Lea","family":"Tuzovic","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kwame","family":"Anyane-Yeboa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ashley","family":"Mills","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kenneth","family":"Glassberg","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9124-390X","authenticated-orcid":false,"given":"Russell","family":"Miller","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2014,2,21]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.2214\/ajr.126.5.957"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1007\/s00383-011-2954-9"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1136\/jmg.23.4.360"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1136\/jmg.26.1.66"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1136\/jmg.25.5.350"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1002\/pd.1970140213"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1016\/S0368-2315(04)96553-2"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1136\/adc.59.2.169"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1002\/pd.114"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1016\/S0090-4295(03)00332-7"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1016\/j.urology.2009.02.071"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1111\/j.1447-0756.1993.tb00397.x"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0223(200009)20:9<697::AID-PD891>3.0.CO;2-O"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1016\/S0090-4295(00)00499-4"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0096(199805)26:4<217::AID-JCU8>3.0.CO;2-G"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1016\/S0090-4295(02)01595-9"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1055\/s-2003-40610"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.2214\/ajr.133.4.749"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1055\/s-2007-999883"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1002\/pd.1970100605"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1002\/pd.1088"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1136\/jmg.26.6.403"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1080\/jmf.16.2.140.141"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1002\/uog.81"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.3109\/00016349209006237"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.1055\/s-2004-821208"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.1002\/jcu.1870120915"},{"key":"ref28","doi-asserted-by":"publisher","DOI":"10.1002\/jcu.1870140617"}],"container-title":["Fetal Diagnosis and Therapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/357703","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/357703","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T18:30:48Z","timestamp":1745433048000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000357703"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014]]},"references-count":28,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2014,7,1]]},"published-print":{"date-parts":[[2014,7,10]]}},"URL":"https:\/\/doi.org\/10.1159\/000357703","archive":["Portico"],"relation":{},"ISSN":["1015-3837","1421-9964"],"issn-type":[{"value":"1015-3837","type":"print"},{"value":"1421-9964","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014]]}}}