{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,13]],"date-time":"2026-03-13T13:28:51Z","timestamp":1773408531174,"version":"3.50.1"},"reference-count":19,"publisher":"S. Karger AG","issue":"3","license":[{"start":{"date-parts":[[2014,1,1]],"date-time":"2014-01-01T00:00:00Z","timestamp":1388534400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2014,1,1]],"date-time":"2014-01-01T00:00:00Z","timestamp":1388534400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int Arch Allergy Immunol"],"published-print":{"date-parts":[[2014]]},"abstract":"<b><i>Background:<\/i><\/b> Anisakiasis is caused by the consumption of raw or undercooked fish or cephalopods parasitized by live L3 larvae of nematode <i>Anisakis <\/i>spp. Larvae anchor to stomach mucosa releasing excretion\/secretion products which contain the main allergens. It has been described that nematode larvae release venom allergen-like proteins among their excretion\/secretion products. We investigated potential cross-reactivity between <i>Anisakis <\/i>and wasp venom allergens. <b><i>Methods:<\/i><\/b> Two groups of 25 patients each were studied: wasp venom- and <i>Anisakis-<\/i>allergic patients. Sera from patients were tested by ImmunoCAP, dot-blotting with recombinant <i>Anisakis<\/i> allergens and ADVIA-Centaur system with Hymenoptera allergens. Cross-reactivity was assessed by IgE immunoblotting inhibition assays. Role of cross-reactive carbohydrate determinants (CCDs) was studied by inhibition with bromelain and periodate treatment. <b><i>Results:<\/i><\/b> A total of 40% of wasp venom-allergic patients had specific IgE to <i>Anisakis simplex <\/i>and 20% detected at least one of the <i>Anisakis<\/i> recombinant allergens tested. Likewise, 44% of <i>Anisakis-<\/i>allergic patients had specific IgE to <i>Vespula <\/i>spp<i>.<\/i> venom and 16% detected at least one of the Hymenoptera allergens tested. Wasp venom-allergic patients detected CCDs in <i>Anisakis<\/i> extract and peptide epitopes on <i>Anisakis <\/i>allergens rAni s 1 and rAni s 9, whereas <i>Anisakis-<\/i>allergic patients only detected CCDs on nVes v 1 allergen from <i>Vespula <\/i>spp. venom. The only <i>Anisakis<\/i> allergen inhibited by <i>Vespula <\/i>venom was rAni s 9. <b><i>Conclusions:<\/i><\/b> This is the first time that cross-sensitization between wasp venom and <i>Anisakis <\/i>is described. CCDs are involved in both cases; however, peptide epitopes are only recognized by wasp venom-allergic patients.<\/jats:p>","DOI":"10.1159\/000358060","type":"journal-article","created":{"date-parts":[[2014,2,13]],"date-time":"2014-02-13T10:43:56Z","timestamp":1392288236000},"page":"179-184","source":"Crossref","is-referenced-by-count":16,"title":["Cross-Reactivity between <b><i>Anisakis<\/i><\/b> spp. and Wasp Venom Allergens"],"prefix":"10.1159","volume":"163","author":[{"given":"Rosa","family":"Rodr\u00edguez-P\u00e9rez","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rafael I.","family":"Monsalve","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Agustin","family":"Gal\u00e1n","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Teresa","family":"Perez-Pi\u00f1ar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ana","family":"Umpierrez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Magdalena","family":"Lluch-Bernal","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francisco","family":"Polo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mar\u00eda Luisa","family":"Caballero","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2014,2,13]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1007\/s00436-004-1154-0"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1016\/S0091-6749(95)70301-2"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.00012-07"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1159\/000084225"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.1997.tb02603.x"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1016\/S0166-6851(01)00374-7"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1159\/000322847"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/170.4.918"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1034\/j.1398-9995.2001.00798.x"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.1997.tb02594.x"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1016\/j.molbiopara.2007.04.005"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1016\/j.molbiopara.2008.02.008"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1016\/j.parint.2011.01.003"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.2011.02781.x"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1159\/000331581"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1159\/000322279"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2222.2009.03324.x"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.2006.01048.x"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-3038.2009.00894.x"}],"container-title":["International Archives of Allergy and Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/358060","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/358060","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T18:33:54Z","timestamp":1745433234000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000358060"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014]]},"references-count":19,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2014,4,1]]},"published-print":{"date-parts":[[2014,4,3]]}},"URL":"https:\/\/doi.org\/10.1159\/000358060","archive":["Portico"],"relation":{"is-supplemented-by":[{"id-type":"doi","id":"10.6084\/m9.figshare.5126104","asserted-by":"subject"}]},"ISSN":["1018-2438","1423-0097"],"issn-type":[{"value":"1018-2438","type":"print"},{"value":"1423-0097","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014]]}}}