{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,30]],"date-time":"2026-08-30T16:31:23Z","timestamp":1788107483948,"version":"build-2803163510"},"reference-count":12,"publisher":"S. Karger AG","issue":"3-4","license":[{"start":{"date-parts":[[2014,2,4]],"date-time":"2014-02-04T00:00:00Z","timestamp":1391472000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2014,2,4]],"date-time":"2014-02-04T00:00:00Z","timestamp":1391472000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nephron Clin Pract"],"abstract":"<jats:p>&lt;b&gt;&lt;i&gt;Background:&lt;\/i&gt;&lt;\/b&gt; Guillain-Barr\u00e9 syndrome (GBS) is an acute polyneuropathy caused by an autoimmune response towards a foreign antigen, notably viral infections. It is characterised by a symmetrical ascending paralysis with treatment remaining largely supportive; however, plasma exchange or intravenous immunoglobulins can be used to shorten recovery time. &lt;b&gt;&lt;i&gt;Case Report:&lt;\/i&gt;&lt;\/b&gt; We describe a case of severe acute GBS in a patient post-renal transplantation. The 44-year-old gentleman's induction therapy consisted of methyl prednisolone and basiliximab, with subsequent tacrolimus and mycophenolate mofetil as immunosuppressive agents. Tacrolimus was discontinued immediately on suspicion of a temporal relationship with the patient's condition, and substituted with a combination of ciclosporin, mycophenolate mofetil and prednisolone. Due to extensive patient screening prior to transplant, negative virology\/immunology and normal nerve biopsy findings, both tacrolimus and basiliximab may be indicated as causative agents. &lt;b&gt;&lt;i&gt;Conclusion:&lt;\/i&gt;&lt;\/b&gt; Immunosuppressive-induced GBS should be considered a differential diagnosis in patients on tacrolimus or basiliximab with acute-onset limb weakness, especially if recently commenced. Discontinuation of tacrolimus and initiation of plasma exchange for the treatment for tacrolimus-associated GBS may be beneficial.<\/jats:p>","DOI":"10.1159\/000358087","type":"journal-article","created":{"date-parts":[[2014,2,4]],"date-time":"2014-02-04T07:49:22Z","timestamp":1391500162000},"page":"239-242","source":"Crossref","is-referenced-by-count":10,"title":["Case Report: Guillain-Barre\u0301 Syndrome following Renal Transplantation - A Diagnostic Dilemma"],"prefix":"10.1159","volume":"124","author":[{"given":"Adam D.","family":"Jakes","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Poonam","family":"Jani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sunil","family":"Bhandari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2014,2,4]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1016%2FS0165-5728%2899%2900195-2"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1016%2FS0140-6736%2805%2967665-9"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1212%2FWNL.0b013e318207b1f6"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1097%2F00007691-199512000-00010"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1002%2Fmus.880170510"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.transproceed.2007.06.088"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.healun.2006.09.014"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.healun.2005.06.012"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1212%2FWNL.40.2.215"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1002%2F%28SICI%291097-4598%28199708%2920%3A8%3C1002%3A%3AAID-MUS10%3E3.0.CO%3B2-X"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1136%2Fjcp.2004.020354"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1468-1331.2012.03730.x"}],"container-title":["Nephron Clinical Practice"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/358087","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/358087","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T18:34:12Z","timestamp":1745433252000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000358087"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,2,4]]},"references-count":12,"journal-issue":{"issue":"3-4","published-online":{"date-parts":[[2014,2,1]]},"published-print":{"date-parts":[[2014,2,13]]}},"URL":"https:\/\/doi.org\/10.1159\/000358087","archive":["Portico"],"relation":{},"ISSN":["1660-2110"],"issn-type":[{"value":"1660-2110","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,2,4]]}}}