{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,18]],"date-time":"2026-01-18T03:05:29Z","timestamp":1768705529813,"version":"3.49.0"},"reference-count":39,"publisher":"S. Karger AG","issue":"5","license":[{"start":{"date-parts":[[2014,1,1]],"date-time":"2014-01-01T00:00:00Z","timestamp":1388534400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2014,1,1]],"date-time":"2014-01-01T00:00:00Z","timestamp":1388534400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Respiration"],"published-print":{"date-parts":[[2014]]},"abstract":"<b><i>Background:<\/i><\/b> Eicosanoids are small lipid molecules with diverse biological functions in the airways. <b><i>Objectives:<\/i><\/b> The aim of this study was to investigate changes in leukotriene B<sub>4<\/sub> (LTB<sub>4<\/sub>), 8-isoprostane, prostaglandin E<sub>2<\/sub> (PGE<sub>2<\/sub>) and cysteinyl-leukotriene (cys-LT) levels in the sputum of patients with chronic obstructive pulmonary disease (COPD) at the onset of a severe exacerbation and during the course of recovery. <b><i>Methods:<\/i><\/b> Thirty-seven ex-smoker COPD patients suffering an episode of acute exacerbation were enrolled. Samples were taken (i) on hospital admission and (ii) after regular treatment. Twenty-five stable ex-smoker COPD patients served as controls. Eicosanoids were determined by enzyme immunoassay. <b><i>Results:<\/i><\/b> Sputum PGE<sub>2<\/sub> [39.8 (13.3-103.3) vs. 5.05 (2.3-12.1) pg\/ml, p < 0.001], 8-isoprostane [89.5 (36.9-184.7) vs. 29.7 (13.8-68.8) pg\/ml, p < 0.01] and LTB<sub>4<\/sub> [587.7 (252.9-774.8) vs. 276.1 (105.4-594.7) pg\/ml, p < 0.05] levels were increased in patients with exacerbation compared to stable subjects. After treatment only PGE<sub>2<\/sub> levels decreased significantly [at discharge: 19.6 (4.6-52.5) pg\/ml, p < 0.01], the levels of other eicosanoids remained elevated (p = NS). Sputum cys-LT levels were similar in stable patients and in those with exacerbation and treatment did not influence cys-LTs either. There was a significant correlation between PGE<sub>2<\/sub> and sputum neutrophil and lymphocyte cell counts in patients with exacerbation. <b><i>Conclusions:<\/i><\/b> Our results suggest that 8-isoprostane, LTB<sub>4<\/sub> and PGE<sub>2<\/sub> but not cys-LTs may be involved in exacerbation-associated inflammatory processes in the airways of patients with COPD. Validation of PGE<sub>2<\/sub> for use as a biomarker of recovery from an exacerbation requires further studies.<\/jats:p>","DOI":"10.1159\/000358099","type":"journal-article","created":{"date-parts":[[2014,4,14]],"date-time":"2014-04-14T07:04:08Z","timestamp":1397459048000},"page":"408-415","source":"Crossref","is-referenced-by-count":21,"title":["Sputum Eicosanoid Profiling in Exacerbations of Chronic Obstructive Pulmonary Disease"],"prefix":"10.1159","volume":"87","author":[{"given":"Orsolya","family":"Drozdovszky","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Imre","family":"Barta","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Balazs","family":"Antus","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2014,4,4]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.2174\/138920111795909087"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.2147\/COPD.S4854"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1034\/j.1399-3003.2000.15b09.x"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2222.2012.03982.x"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(95)90409-3"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1136\/thorax.58.7.585"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1152\/ajplung.90593.2008"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.5114\/aoms.2012.28555"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1378\/chest.11-1581"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.03.00017003a"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1136\/thorax.58.4.294"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2004.10.007"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1016\/j.rmed.2005.03.033"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.05.00029705"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1159\/000206010"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200703-456SO"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201003-0451OC"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1007\/s00011-012-0508-9"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00151905"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1159\/000330667"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2222.2009.03386.x"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1843.2008.01365.x"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1006\/bbrc.1997.7064"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201001-0055OC"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1186\/1465-9921-9-16"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00008707"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.1378\/chest.08-2782"},{"key":"ref28","doi-asserted-by":"publisher","DOI":"10.1111\/resp.12089"},{"key":"ref29","doi-asserted-by":"publisher","DOI":"10.1159\/000324542"},{"key":"ref30","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1843.2012.02216.x"},{"key":"ref31","doi-asserted-by":"publisher","DOI":"10.1159\/000332835"},{"key":"ref32","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.162.3.2001063"},{"key":"ref33","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00023606"},{"key":"ref34","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.154.3.8810624"},{"key":"ref35","doi-asserted-by":"publisher","DOI":"10.1016\/j.rmed.2011.06.015"},{"key":"ref36","doi-asserted-by":"publisher","DOI":"10.1136\/thorax.58.6.505"},{"key":"ref37","doi-asserted-by":"publisher","DOI":"10.1159\/000334900"},{"key":"ref38","doi-asserted-by":"publisher","DOI":"10.1378\/chest.06-2216"},{"key":"ref39","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.03.00022203"}],"container-title":["Respiration"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/358099","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/358099","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T18:34:17Z","timestamp":1745433257000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000358099"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014]]},"references-count":39,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2014,4,1]]},"published-print":{"date-parts":[[2014,4,28]]}},"URL":"https:\/\/doi.org\/10.1159\/000358099","archive":["Portico"],"relation":{"is-supplemented-by":[{"id-type":"doi","id":"10.6084\/m9.figshare.5126119","asserted-by":"subject"}]},"ISSN":["0025-7931","1423-0356"],"issn-type":[{"value":"0025-7931","type":"print"},{"value":"1423-0356","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014]]}}}