{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T05:07:55Z","timestamp":1789967275076,"version":"4.0.1"},"reference-count":36,"publisher":"S. Karger AG","issue":"4","license":[{"start":{"date-parts":[[2014,1,1]],"date-time":"2014-01-01T00:00:00Z","timestamp":1388534400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2014,1,1]],"date-time":"2014-01-01T00:00:00Z","timestamp":1388534400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Innate Immun"],"published-print":{"date-parts":[[2014]]},"abstract":"<i>Streptococcus pneumoniae<\/i> is a common cause of pneumonia and sepsis. Toll-like receptors (TLRs) play a pivotal role in the host defense against infection. In this study, we sought to determine the role of single immunoglobulin interleukin-1 receptor-related molecule (SIGIRR a.k.a. TIR8), a negative regulator of TLR signaling, in pneumococcal pneumonia and sepsis<i>.<\/i> Wild-type and SIGIRR-deficient (<i>sigirr-\/-<\/i>) mice were infected intranasally (to induce pneumonia) or intravenously (to induce primary sepsis) with <i>S. pneumoniae<\/i> and euthanized after 6, 24, or 48 h for analyses. Additionally, survival studies were performed. <i>sigirr-\/-<\/i> mice showed delayed mortality during lethal pneumococcal pneumonia. Accordingly, <i>sigirr-\/-<\/i> mice displayed lower bacterial loads in lungs and less dissemination of the infection 24 h after the induction of pneumonia. SIGIRR deficiency was associated with increased interstitial and perivascular inflammation in lung tissue early after infection, with no impact on neutrophil recruitment or cytokine production. <i>sigirr-\/-<\/i> mice also demonstrated reduced bacterial burdens at multiple body sites during <i>S. pneumoniae <\/i>sepsis. <i>sigirr-\/-<\/i> alveolar macrophages and neutrophils exhibited an increased capacity to phagocytose viable pneumococci. These results suggest that SIGIRR impairs the antibacterial host defense during pneumonia and sepsis caused by <i>S. pneumoniae<\/i>.<\/jats:p>","DOI":"10.1159\/000358239","type":"journal-article","created":{"date-parts":[[2017,4,18]],"date-time":"2017-04-18T21:47:17Z","timestamp":1492552037000},"page":"542-552","source":"Crossref","is-referenced-by-count":21,"title":["Single Immunoglobulin Interleukin-1 Receptor-Related Molecule Impairs Host Defense during Pneumonia and Sepsis Caused by <b><i>Streptococcus Pneumoniae<\/i><\/b>"],"prefix":"10.1159","volume":"6","author":[{"given":"Dana C.","family":"Blok","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miriam H.P.","family":"van Lieshout","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arie 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