{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,6]],"date-time":"2025-11-06T06:03:10Z","timestamp":1762408990089,"version":"3.40.5"},"reference-count":8,"publisher":"S. Karger AG","issue":"3","license":[{"start":{"date-parts":[[2014,1,1]],"date-time":"2014-01-01T00:00:00Z","timestamp":1388534400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2014,1,1]],"date-time":"2014-01-01T00:00:00Z","timestamp":1388534400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Dermatology"],"published-print":{"date-parts":[[2014]]},"abstract":"<jats:p>Background\/Aims: Prurigo nodularis (PN) has multiple reported disease associations, and this study analyzes the demographics, clinical distribution and underlying etiologies in an Asian cohort. Methods: A 1-year retrospective study was carried out on PN patients with extensive lesions (\u226510) who attended a specialized itch clinic. Results: 37 patients (46% male, median age 53 years) were included. In all patients, an underlying etiologic factor associated with pruritus could be identified. 49% (n = 18) of patients had a single attributable etiology, whilst 51% (n = 19) had multiple etiologies. Among all patients, dermatological disease was the most common cause (82%), of which endogenous eczema comprised the majority of cases (54%), followed by systemic disease (38%). Conclusions: All patients with extensive PN had identifiable factors associated with pruritus in this study, and a dermatological condition was the predominant etiology in both patients with mono- and multifactorial disease. A significant number of patients had underlying systemic causes.<\/jats:p>","DOI":"10.1159\/000358250","type":"journal-article","created":{"date-parts":[[2014,3,24]],"date-time":"2014-03-24T07:39:36Z","timestamp":1395646776000},"page":"276-280","source":"Crossref","is-referenced-by-count":27,"title":["Extensive Prurigo Nodularis: Characterization and Etiology"],"prefix":"10.1159","volume":"228","author":[{"given":"Wei Sheng","family":"Tan","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8894-6711","authenticated-orcid":false,"given":"Hong Liang","family":"Tey","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2014,3,22]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-3083.2012.04481.x"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1525-1470.1990.tb00670.x"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-0960.2005.00187.x"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.3109\/09546631003674321"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1159\/000246715"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.1985.tb02357.x"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.1993.01680280049009"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1016\/S1590-8658(00)80847-6"}],"container-title":["Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/358250","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/358250","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T18:36:00Z","timestamp":1745433360000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000358250"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014]]},"references-count":8,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2014,6,1]]},"published-print":{"date-parts":[[2014,6,10]]}},"URL":"https:\/\/doi.org\/10.1159\/000358250","archive":["Portico"],"relation":{},"ISSN":["1018-8665","1421-9832"],"issn-type":[{"type":"print","value":"1018-8665"},{"type":"electronic","value":"1421-9832"}],"subject":[],"published":{"date-parts":[[2014]]}}}