{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,3]],"date-time":"2025-10-03T08:51:55Z","timestamp":1759481515538,"version":"3.40.4"},"reference-count":25,"publisher":"S. Karger AG","issue":"2","license":[{"start":{"date-parts":[[2014,1,1]],"date-time":"2014-01-01T00:00:00Z","timestamp":1388534400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2014,1,1]],"date-time":"2014-01-01T00:00:00Z","timestamp":1388534400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Am J Nephrol"],"published-print":{"date-parts":[[2014]]},"abstract":"<jats:p>&lt;b&gt;&lt;i&gt;Background\/Aims:&lt;\/i&gt;&lt;\/b&gt; Chronic kidney disease (CKD) is common in the general population, may lead to end-stage renal disease, and is most frequently found among males. Familial clustering of kidney diseases has been observed. We aimed to study a potential association between the family history of myocardial infarction (MI) and renal dysfunction. &lt;b&gt;&lt;i&gt;Methods: &lt;\/i&gt;&lt;\/b&gt;22,297 males and 10,828 females, aged 33-60 years, from a population-based cohort study were studied. Estimated glomerular filtration rate (eGFR) was assessed by the CKD-EPI creatinine equation. Every participant filled in a self-administered questionnaire including family history. Heredity for MI was defined as mother or father having had MI and\/or died from MI, and\/or brother or sister having had MI. Binary logistic regression and multiple linear regression were used in the analyses. &lt;b&gt;&lt;i&gt;Results:&lt;\/i&gt;&lt;\/b&gt; Multiple linear regression revealed a significantly increased risk of renal dysfunction in those with a positive heredity for MI (the whole cohort p = 0.01, males p = 0.000, females p = 0.169). Binary logistic regression showed that males with heredity for MI with a mean age of 43 years have a 2 times higher risk (p = 0.02) of belonging to the group with GFR &lt;45 ml\/min\/1.73 m&lt;sup&gt;2&lt;\/sup&gt; compared to those without heredity. For the whole cohort the increased risk was 1.6 times (p = 0.07). There was no significant association for females (p = 0.88). &lt;b&gt;&lt;i&gt;Conclusion:&lt;\/i&gt;&lt;\/b&gt; These findings demonstrate that a familial burden of MI is associated with renal dysfunction, in men, already in middle age. Genetic variants may underlie predisposition to CKD in those with heredity for MI.<\/jats:p>","DOI":"10.1159\/000358259","type":"journal-article","created":{"date-parts":[[2014,1,30]],"date-time":"2014-01-30T07:37:02Z","timestamp":1391067422000},"page":"85-91","source":"Crossref","is-referenced-by-count":3,"title":["Family History of Myocardial Infarction Increases Risk of Renal Dysfunction in Middle Age"],"prefix":"10.1159","volume":"39","author":[{"given":"Anders","family":"Christensson","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Olle","family":"Melander","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Erik","family":"Fjellstedt","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria","family":"Ohlson-Andersson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2014,1,30]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1001%2Fjama.298.17.2038"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1681%2FASN.2005121273"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1161%2F01.CIR.0000095676.90936.80"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1136%2Fheart.89.9.963"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1002%2Fijc.28144"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.jacc.2008.07.051"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1038%2Fncpneph0673"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1001%2Farchinte.165.19.2299"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1152%2Fajprenal.00159.2004"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1001%2Farchinte.155.11.1201"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1007%2Fs11906-011-0237-4"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1525-139X.2007.00282.x"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1161%2FCIRCULATIONAHA.107.183679"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1038%2Fncpcardio0982"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1046%2Fj.1365-2796.1996.483819000.x"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1046%2Fj.1365-2796.2000.00568.x"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.7326%2F0003-4819-150-9-200905050-00006"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1159%2F000180580"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1001%2Farchinte.1916.00080130010002"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.7326%2F0003-4819-145-4-200608150-00004"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1161%2F01.CIR.61.3.503"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1038%2Fng.327"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1038%2Fng.307"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1126%2Fscience.1142842"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1056%2FNEJMoa072366"}],"container-title":["American Journal of Nephrology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/358259","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/358259","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T18:36:02Z","timestamp":1745433362000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000358259"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014]]},"references-count":25,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2014,3,1]]},"published-print":{"date-parts":[[2014,3,12]]}},"URL":"https:\/\/doi.org\/10.1159\/000358259","archive":["Portico"],"relation":{},"ISSN":["0250-8095","1421-9670"],"issn-type":[{"type":"print","value":"0250-8095"},{"type":"electronic","value":"1421-9670"}],"subject":[],"published":{"date-parts":[[2014]]}}}