{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T03:21:36Z","timestamp":1783480896487,"version":"3.55.0"},"reference-count":16,"publisher":"S. Karger AG","issue":"3","license":[{"start":{"date-parts":[[2014,1,1]],"date-time":"2014-01-01T00:00:00Z","timestamp":1388534400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2014,1,1]],"date-time":"2014-01-01T00:00:00Z","timestamp":1388534400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cardiology"],"published-print":{"date-parts":[[2014]]},"abstract":"<b><i>Objectives:<\/i><\/b> This study aimed to evaluate factors associated with the prescription of high-dose potent statin (HDPS) therapy following hospitalization for acute coronary events. <b><i>Study Design:<\/i><\/b> Sub-analysis was made using the data of 3,525 patients enrolled in the 2008 and 2010 Acute Coronary Syndrome Israeli Surveys (ACSIS). <b><i>Methods:<\/i><\/b> Analyses were carried out to identify demographic and clinical factors associated with the prescription of HDPS therapy (atorvastatin 40-80 mg\/day or rosuvastatin 20-40 mg\/day) at discharge compared with the prescription of lower-dose statins. <b><i>Results:<\/i><\/b> Among the study patients, 1,387 (39%) were discharged on HDPS, 1,860 (53%) with lower-dose statin regimens and 278 (8%) with no recommendation for statin therapy. Multivariate logistic regression analysis showed that pre-admission usage of HDPS and participation in the more recent (2010) ACSIS survey were independently associated with a higher likelihood of HDPS prescription at discharge from the index event (odds ratio, OR, 21.07, p < 0.001, and 5.61, p < 0.001, respectively), whereas factors independently associated with a lack of HDPS prescription included age >75 years (OR 0.76, p = 0.03), low-density lipoprotein-cholesterol levels <100 mg\/dl on admission (OR 0.67, p < 0.001) and a history of heart failure prior to the index hospitalization (OR 0.54, p = 0.0018). The 30-day compliance with the HDPS regimen was 98%. <b><i>Conclusions:<\/i><\/b> The findings show increased use of HDPS therapy in acute coronary syndrome (ACS) patients, although this mode of medical therapy is still underutilized in the important subset of high-risk ACS patients.<\/jats:p>","DOI":"10.1159\/000358378","type":"journal-article","created":{"date-parts":[[2014,6,2]],"date-time":"2014-06-02T09:59:14Z","timestamp":1401703154000},"page":"266-272","source":"Crossref","is-referenced-by-count":3,"title":["Temporal Trends in the Use of High-Dose Potent Statins following Acute Coronary Syndrome in Israel"],"prefix":"10.1159","volume":"128","author":[{"given":"Avishay","family":"Elis","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Pereg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dror","family":"Dicker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natalie","family":"Gevrielov-Yusim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ilan","family":"Goldenberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shlomi","family":"Matetzky","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eran","family":"Kopel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"Klempfner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2014,5,24]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2007.02.013"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehr158"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2009.05.062"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1378\/chest.128.5.3641"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1001\/jama.285.13.1711"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2005.03.077"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2011.07.064"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1016\/j.ahj.2010.09.008"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1002\/ccd.23426"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1007\/s11606-010-1473-z"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2006.09.111"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejim.2011.06.003"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1111\/j.1751-7133.2010.00165.x"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2010.02.019"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1001\/jama.288.4.455"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.2146\/ajhp040419"}],"container-title":["Cardiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/358378","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/358378","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/358378","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T18:36:42Z","timestamp":1745433402000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000358378"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014]]},"references-count":16,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2014,6,1]]},"published-print":{"date-parts":[[2014,6,20]]}},"URL":"https:\/\/doi.org\/10.1159\/000358378","archive":["Portico"],"relation":{},"ISSN":["0008-6312","1421-9751"],"issn-type":[{"value":"0008-6312","type":"print"},{"value":"1421-9751","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014]]}}}