{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,18]],"date-time":"2026-05-18T14:31:56Z","timestamp":1779114716337,"version":"3.51.4"},"reference-count":19,"publisher":"S. Karger AG","issue":"3","license":[{"start":{"date-parts":[[2014,1,1]],"date-time":"2014-01-01T00:00:00Z","timestamp":1388534400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2014,1,1]],"date-time":"2014-01-01T00:00:00Z","timestamp":1388534400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cardiology"],"published-print":{"date-parts":[[2014]]},"abstract":"<jats:p>&lt;b&gt;&lt;i&gt;Objective:&lt;\/i&gt;&lt;\/b&gt; The systematic pro-inflammatory responses after percutaneous coronary intervention with drug-eluting stents (DES) remain poorly defined. Therefore, we compared the systematic pro-inflammatory state of circulating mononuclear cells (MNCs) between DES and bare metal stent (BMS) implantation. &lt;b&gt;&lt;i&gt;Methods:&lt;\/i&gt;&lt;\/b&gt; Patients with indications for treatment with stents were randomized in a 1:1 ratio to placement of DES or BMS. The primary endpoint was a change of pro-inflammatory state at 12 weeks post-procedure. &lt;b&gt;&lt;i&gt;Results:&lt;\/i&gt;&lt;\/b&gt; Thirty-six consecutive patients received DES or BMS. At 12 weeks after stent implantation, the lipid profile and high-sensitivity C-reactive protein (hs-CRP) improved significantly in both groups. The mRNA levels and plasma concentrations of interleukin-6, tumor necrosis factor-a and matrix metalloproteinase-9 were significantly elevated in the DES group, which was not observed in the BMS group. An increase in NF-&amp;#947;B binding activity and a decrease in PPAR-&amp;#947; expression in MNCs were observed in the DES group, along with increases in I&amp;#947;B phosphorylation and p50 expression. However, similar changes were not observed in the BMS group. &lt;b&gt;&lt;i&gt;Conclusions:&lt;\/i&gt;&lt;\/b&gt; Systematic inflammatory responses were accentuated after the patients were treated percutaneously with DES, despite their improved lipid profile and hs-CRP. These data may provide fundamental information for optimizing therapeutic strategy in the era of DES.<\/jats:p>","DOI":"10.1159\/000358508","type":"journal-article","created":{"date-parts":[[2014,5,16]],"date-time":"2014-05-16T06:49:36Z","timestamp":1400222976000},"page":"259-265","source":"Crossref","is-referenced-by-count":5,"title":["Drug-Eluting Stent, but Not Bare Metal Stent, Accentuates the Systematic Inflammatory Response in Patients"],"prefix":"10.1159","volume":"128","author":[{"given":"Junhui","family":"Liu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiao-Zhen","family":"Zhuo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Weimin","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhaofei","family":"Wan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xinhong","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Weiping","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shanshan","family":"Gao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zuyi","family":"Yuan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yue","family":"Wu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2014,5,16]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa035071"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1159\/000348319"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.107.730010"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2010.05.066"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1136\/hrt.2009.192393"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000142055.53122.FA"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.2337\/dc11-0091"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2010.12.007"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-8703(03)00407-1"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2006.04.034"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/cvp388"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0b013e318212bb8b"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1159\/000338166"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1159\/000347134"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2010.12.008"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1038\/cr.2011.13"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1101\/gad.183434.111"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2011.07.112"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.107.164384"}],"container-title":["Cardiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/358508","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/358508","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T18:37:54Z","timestamp":1745433474000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000358508"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014]]},"references-count":19,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2014,6,1]]},"published-print":{"date-parts":[[2014,6,20]]}},"URL":"https:\/\/doi.org\/10.1159\/000358508","archive":["Portico"],"relation":{"is-supplemented-by":[{"id-type":"doi","id":"10.6084\/m9.figshare.5126197","asserted-by":"subject"}]},"ISSN":["0008-6312","1421-9751"],"issn-type":[{"value":"0008-6312","type":"print"},{"value":"1421-9751","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014]]}}}