{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,24]],"date-time":"2026-06-24T14:22:23Z","timestamp":1782310943745,"version":"3.54.5"},"reference-count":21,"publisher":"S. Karger AG","issue":"1","license":[{"start":{"date-parts":[[2014,1,1]],"date-time":"2014-01-01T00:00:00Z","timestamp":1388534400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/3.0\/"},{"start":{"date-parts":[[2014,1,1]],"date-time":"2014-01-01T00:00:00Z","timestamp":1388534400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Obes Facts"],"published-print":{"date-parts":[[2014]]},"abstract":"<b><i>Objective:<\/i><\/b> Patients with Prader-Willi syndrome (PWS) have been hypothesized to be at lower risk of non-alcoholic fatty liver disease (NAFLD) because of higher insulin sensitivity. However, PWS patients have a peculiar body composition, i.e. higher fat mass and lower fat-free mass, which may confound such associations. We evaluated whether NAFLD is less frequent in PWS than in non-PWS women matched on percent body fat (PBF). <b><i>Methods:<\/i><\/b> PBF was measured by dual-energy X-ray absorptiometry. Liver fat was assessed by ultrasonography. Insulin sensitivity and beta-cell function were evaluated by oral glucose tolerance testing. Coarsened exact matching (CEM) was used to match PWS and non-PWS women on PBF. General and generalized linear models taking CEM into account were used to perform comparisons between PWS and non-PWS women. <b><i>Results:<\/i><\/b> 20 women with PWS were matched to 27 women without PWS on the basis of PBF (mean 53 vs. 54%, p = 0.6). Insulin sensitivity and beta-cell function were similar in the two groups. However, the prevalence of NAFLD was 25% in PWS versus 59% in non-PWS women (p = 0.04). <b><i>Conclusion:<\/i><\/b> NAFLD is less frequent in PWS than in non-PWS women but this finding is not associated with higher insulin sensitivity.<\/jats:p>","DOI":"10.1159\/000358570","type":"journal-article","created":{"date-parts":[[2014,2,25]],"date-time":"2014-02-25T08:16:24Z","timestamp":1393316184000},"page":"71-76","source":"Crossref","is-referenced-by-count":24,"title":["Is Non-Alcoholic Fatty Liver Disease Less Frequent among Women with Prader-Willi Syndrome?"],"prefix":"10.1159","volume":"7","author":[{"given":"Giorgio","family":"Bedogni","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Graziano","family":"Grugni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valerio","family":"Nobili","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fiorenza","family":"Agosti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonella","family":"Saezza","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandro","family":"Sartorio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2014,2,22]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1038\/gim.0b013e31822bead0"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1136\/jmg.38.11.792"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1016\/S0026-0495(98)90003-8"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1038\/oby.2006.193"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.3275\/8242"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2010-1733"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.22.9.1462"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1016\/j.numecd.2010.05.003"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-003-1263-9"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2008.01948.x"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1038\/ejcn.2013.159"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1017\/S0007114508922558"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1038\/oby.2009.162"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1097\/MPG.0b013e31821b4b61"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ejcn.1602588"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1198\/jasa.2011.tm09599"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1186\/1471-230X-6-33"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1111\/j.2047-6310.2012.00089.x"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2265.2011.04303.x"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1097\/00125817-199811000-00010"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2010.04.008"}],"container-title":["Obesity Facts"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/358570","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/358570","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T18:38:19Z","timestamp":1745433499000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000358570"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014]]},"references-count":21,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2014,2,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000358570","archive":["Portico"],"relation":{},"ISSN":["1662-4025","1662-4033"],"issn-type":[{"value":"1662-4025","type":"print"},{"value":"1662-4033","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014]]}}}