{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T13:18:25Z","timestamp":1761743905765,"version":"3.40.4"},"reference-count":16,"publisher":"S. Karger AG","issue":"2","license":[{"start":{"date-parts":[[2014,1,1]],"date-time":"2014-01-01T00:00:00Z","timestamp":1388534400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2014,1,1]],"date-time":"2014-01-01T00:00:00Z","timestamp":1388534400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Intervirology"],"published-print":{"date-parts":[[2014]]},"abstract":"<jats:p>&lt;b&gt;&lt;i&gt;Objective:&lt;\/i&gt;&lt;\/b&gt; To evaluate the prevalence of human herpesviruses (HHV) 1-6 and community-acquired respiratory viruses (CARVs) in specimens from patients with nasal polyposis undergoing functional endoscopic sinus surgery (FESS) and investigate the potential clinical role. &lt;b&gt;&lt;i&gt;Methods:&lt;\/i&gt;&lt;\/b&gt; Viral occurrence was evaluated by molecular methods in polyp, turbinate mucosa, and pre- and postoperative scraping specimens from 35 consecutive patients at different time points in relation to FESS. &lt;b&gt;&lt;i&gt;Results:&lt;\/i&gt;&lt;\/b&gt; Overall, 21 patients (60%) were positive to at least one virus in at least one specimen; in particular, 12.1% of all specimens for HHV-6 (3\/35 polyps, 11\/31 turbinates, 1 presurgical scraping) and 10.5% for Epstein-Barr virus (EBV) (8\/35 polyps, 3\/31 turbinates, 1\/29 pre- and 1\/29 postsurgical scraping), followed by CMV and HSV-1 (both 1.6%; 1\/35 polyps, 1\/29 postsurgical scraping and 2\/35 polyps, respectively). EBV positivity tended to be higher in polyps, as well as HHV-6 in adjacent healthy turbinate mucosa, although no significant association was found. Only one preoperative cytological specimen was positive to parainfluenza virus-1. &lt;b&gt;&lt;i&gt;Conclusion:&lt;\/i&gt;&lt;\/b&gt; No association between the development of nasal polyps, herpesviruses and CARVs seems to exist. However, the higher EBV frequency in polyps could suggest a causative role or persistence in the inflammatory lymphoid tissue.<\/jats:p>","DOI":"10.1159\/000358880","type":"journal-article","created":{"date-parts":[[2014,2,17]],"date-time":"2014-02-17T08:20:21Z","timestamp":1392625221000},"page":"101-105","source":"Crossref","is-referenced-by-count":14,"title":["Detection of Herpesviruses 1-6 and Community-Acquired Respiratory Viruses in Patients with Chronic Rhinosinusitis with Nasal Polyposis"],"prefix":"10.1159","volume":"57","author":[{"given":"Cristina","family":"Costa","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Massimiliano","family":"Garzaro","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Valeria","family":"Boggio","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francesca","family":"Sidoti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Salvatore","family":"Simeone","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luca","family":"Raimondo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giovanni Patrick","family":"Cavallo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giancarlo","family":"Pecorari","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rossana","family":"Cavallo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2014,2,15]]},"reference":[{"doi-asserted-by":"publisher","key":"ref1","DOI":"10.2165\/00003495-200161050-00003"},{"doi-asserted-by":"publisher","key":"ref2","DOI":"10.2500\/105065800782102717"},{"doi-asserted-by":"publisher","key":"ref3","DOI":"10.3892\/ijo.31.5.1051"},{"doi-asserted-by":"publisher","key":"ref4","DOI":"10.3892\/or.19.2.385"},{"doi-asserted-by":"publisher","key":"ref5","DOI":"10.1016\/0091-6749(93)90035-E"},{"doi-asserted-by":"publisher","key":"ref6","DOI":"10.1016\/S0091-6749(05)80142-3"},{"doi-asserted-by":"publisher","key":"ref7","DOI":"10.1097\/01.mlg.0000224526.43698.52"},{"doi-asserted-by":"publisher","key":"ref8","DOI":"10.3109\/00016489009122573"},{"doi-asserted-by":"publisher","key":"ref9","DOI":"10.1016\/j.canlet.2005.07.019"},{"doi-asserted-by":"publisher","key":"ref10","DOI":"10.1080\/000164800750061750"},{"doi-asserted-by":"publisher","key":"ref11","DOI":"10.1002\/jmv.1890450114"},{"doi-asserted-by":"publisher","key":"ref12","DOI":"10.1002\/jmv.21534"},{"doi-asserted-by":"publisher","key":"ref13","DOI":"10.1002\/hed.21772"},{"doi-asserted-by":"publisher","key":"ref14","DOI":"10.1002\/alr.20030"},{"doi-asserted-by":"publisher","key":"ref15","DOI":"10.2500\/ajr.2006.20.2899"},{"doi-asserted-by":"publisher","key":"ref16","DOI":"10.3201\/eid1708.101944"}],"container-title":["Intervirology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/358880","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/358880","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T17:26:18Z","timestamp":1745429178000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000358880"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014]]},"references-count":16,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2014,3,1]]},"published-print":{"date-parts":[[2014,3,31]]}},"URL":"https:\/\/doi.org\/10.1159\/000358880","archive":["Portico"],"relation":{},"ISSN":["0300-5526","1423-0100"],"issn-type":[{"type":"print","value":"0300-5526"},{"type":"electronic","value":"1423-0100"}],"subject":[],"published":{"date-parts":[[2014]]}}}