{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,24]],"date-time":"2026-04-24T03:53:57Z","timestamp":1777002837141,"version":"3.51.4"},"reference-count":17,"publisher":"S. Karger AG","issue":"1","license":[{"start":{"date-parts":[[2014,3,7]],"date-time":"2014-03-07T00:00:00Z","timestamp":1394150400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2014,3,7]],"date-time":"2014-03-07T00:00:00Z","timestamp":1394150400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nephron Clin Pract"],"abstract":"<b><i>Introduction:<\/i><\/b> Cardiovascular disease is a leading cause of morbidity and mortality after renal transplantation. We analysed whether pre-transplant transthoracic echocardiograms (TTE) predicted major adverse cardiovascular events (MACE) after transplant. <b><i>Methods:<\/i><\/b> We retrospectively analysed clinical and TTE data from patients having renal transplantation at a single centre between 1 January 2000 and 31 December 2010. The TTE were classified as: group A - normal; group B - mild abnormalities expected in renal failure; group C - moderate to severe abnormalities likely to change management. They were also scored based on four independent risk factors [age \u226550, left ventricular (LV) end systolic diameter \u22653.5 cm, LV wall thickness \u22651.4 cm and mitral annulus calcification]. Post-transplantation clinical notes were examined for MACE (death, stroke, myocardial infarction, and surgical or percutaneous revascularisation). <b><i>Results:<\/i><\/b> There were 343 patients, mean age 47 (range 21-83) years, 210 of whom were male. MACE occurred in 29 (8.5%) at a mean of 3.6 (SD 3.3) years after transplantation. They were older (p \u2264 0.001), had larger LV mass (p = 0.02), LV wall thickness (p = 0.008) and left atrial size (p = 0.001) than those without MACE. The MACE rate for groups A, B and C were 1.8, 13.6 and 16.4% (p \u2264 0.001), respectively. Using the score, the risk of MACE was 4.7, 10.7, 9.2 and 40% for scores 0, 1, 2 and 3 (p = 0.023), respectively. <b><i>Conclusion:<\/i><\/b> Preoperative transthoracic echocardiography identifies patients at risk of death or non-fatal cardiovascular events even late after renal transplantation. This suggests that echocardiography might be useful to identify patients requiring more aggressive long-term treatment of modifiable vascular risk factors.<\/jats:p>","DOI":"10.1159\/000358885","type":"journal-article","created":{"date-parts":[[2014,3,7]],"date-time":"2014-03-07T07:46:26Z","timestamp":1394178386000},"page":"75-80","source":"Crossref","is-referenced-by-count":7,"title":["Echocardiography Predicts Major Adverse Cardiovascular Events after Renal Transplantation"],"prefix":"10.1159","volume":"126","author":[{"given":"Haotian","family":"Gu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Majid","family":"Akhtar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amit","family":"Shah","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anjalika","family":"Mallick","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marlies","family":"Ostermann","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John","family":"Chambers","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2014,3,7]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.transproceed.2010.05.077"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1093%2Fndt%2Fgfs542"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1159%2F000328070"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1136%2Fhrt.2006.096826"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1038%2Fki.1995.22"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1097%2FTP.0b013e318188d640"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.atherosclerosis.2006.03.033"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1093%2Fndt%2F15.1.93"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1093%2Fndt%2Fgfq822"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.jacc.2007.09.001"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1093%2Feurheartj%2Fehp337"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.transproceed.2010.05.123"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1038%2Fncpneph0441"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1053%2Fj.ajkd.2009.12.033"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1097%2F01.tp.0000235527.81917.fe"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1681%2FASN.2004070580"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1681%2FASN.2005090984"}],"container-title":["Nephron Clinical Practice"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/358885","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/358885","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T17:26:23Z","timestamp":1745429183000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000358885"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,3,7]]},"references-count":17,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2014,4,1]]},"published-print":{"date-parts":[[2014,4,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000358885","archive":["Portico"],"relation":{},"ISSN":["1660-2110"],"issn-type":[{"value":"1660-2110","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,3,7]]}}}