{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,15]],"date-time":"2026-06-15T11:40:14Z","timestamp":1781523614632,"version":"3.54.1"},"reference-count":31,"publisher":"S. Karger AG","issue":"1","license":[{"start":{"date-parts":[[2014,1,1]],"date-time":"2014-01-01T00:00:00Z","timestamp":1388534400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2014,1,1]],"date-time":"2014-01-01T00:00:00Z","timestamp":1388534400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Ann Nutr Metab"],"published-print":{"date-parts":[[2014]]},"abstract":"<jats:p>&lt;b&gt;&lt;i&gt;Background\/Aims:&lt;\/i&gt;&lt;\/b&gt; Increased triglyceride (TG) and decreased high-density lipoprotein cholesterol (HDL-C) levels are considered risk factors for diabetes among prediabetic subjects. In this study, we retrospectively investigated the relationship between lipid profiles and the rate of change in early-phase insulin secretion in prediabetic subjects. &lt;b&gt;&lt;i&gt;Methods:&lt;\/i&gt;&lt;\/b&gt; To evaluate insulin secretion, 50 prediabetic subjects underwent a 75-gram oral glucose tolerance test at the beginning of the study (baseline), and they were reexamined after a 2-year interval. The results were expressed as insulinogenic index (IGI) and disposition index (DI). &lt;b&gt;&lt;i&gt;Results:&lt;\/i&gt;&lt;\/b&gt; The lipid profiles and indices of insulin secretion had not significantly changed over 2 years. However, Pearson's correlation analyses indicated that the rate of change in IGI and DI was negatively correlated with log-transformed baseline TG level, but not with baseline HDL-C level. Multiple linear regression analysis confirmed that the rate of change in IGI and DI was negatively correlated with the log-transformed baseline TG level (\u03b2 = -0.38, p = 0.006, and \u03b2 = -0.39, p = 0.006, respectively). &lt;b&gt;&lt;i&gt;Conclusions:&lt;\/i&gt;&lt;\/b&gt; Baseline TG level of prediabetic subjects appeared to be associated with rate of change in IGI and DI over a 2-year period, indicating that TG levels among prediabetic subjects should be carefully monitored.<\/jats:p>","DOI":"10.1159\/000360012","type":"journal-article","created":{"date-parts":[[2014,4,9]],"date-time":"2014-04-09T07:20:48Z","timestamp":1397028048000},"page":"38-43","source":"Crossref","is-referenced-by-count":19,"title":["Serum Triglyceride Levels Correlated with the Rate of Change in Insulin Secretion Over Two Years in Prediabetic Subjects"],"prefix":"10.1159","volume":"64","author":[{"given":"Masanori","family":"Shimodaira","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomohiro","family":"Niwa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Koji","family":"Nakajima","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mutsuhiro","family":"Kobayashi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Norinao","family":"Hanyu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomohiro","family":"Nakayama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2014,4,9]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.2337\/dc05-2179"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.2337\/dc08-1195"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-002-1009-0"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.2337\/diabetes.55.04.06.db05-1109"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1016\/S0168-8227(03)00037-8"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1097\/MOL.0b013e32832ac180"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1097\/MOL.0b013e3283412279"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1007\/s001250051041"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1007\/BF00401761"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.191207498"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.95.5.2498"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1007\/s00592-011-0339-0"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.2337\/dc13-S011"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1253\/circj.66.987"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1007\/BF00280883"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.2337\/diabetes.51.7.2170"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.2337\/diabetes.52.9.2304"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1016\/S0168-8227(99)00019-4"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1111\/j.1464-5491.2004.01189.x"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.2337\/dc08-0825"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-007-0893-8"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1001\/jama.285.19.2486"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.2337\/diabetes.51.2007.S212"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.2337\/diab.46.11.1718"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.2337\/diab.45.5.580"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.1210\/en.2003-1602"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.110.207373"},{"key":"ref28","doi-asserted-by":"publisher","DOI":"10.5551\/jat.E599"},{"key":"ref29","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.24.7.1167"},{"key":"ref30","doi-asserted-by":"publisher","DOI":"10.1055\/s-2002-34791"},{"key":"ref31","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajhg.2009.12.009"}],"container-title":["Annals 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