{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T09:12:11Z","timestamp":1778749931955,"version":"3.51.4"},"reference-count":25,"publisher":"S. Karger AG","issue":"2","license":[{"start":{"date-parts":[[2014,1,1]],"date-time":"2014-01-01T00:00:00Z","timestamp":1388534400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2014,1,1]],"date-time":"2014-01-01T00:00:00Z","timestamp":1388534400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neonatology"],"published-print":{"date-parts":[[2014]]},"abstract":"<b><i>Background:<\/i><\/b> Iron deficiency (ID) contributes to anaemia of prematurity, and hence the reliable assessment of iron nutrition status appears to be mandatory. <b><i>Objective:<\/i><\/b> To establish gestational age (GA)-specific reference ranges for hepcidin concentrations in cord blood [Hep<sub>(CB)<\/sub>] of preterm and term infants and to identify pre- and perinatal confounding factors. <b><i>Methods:<\/i><\/b> This is a prospective observational study including 221 infants (GA at birth: 24-42 weeks). Hep<sub>(CB)<\/sub> along with complete blood counts, ferritin and parameters of inflammation and clinical data were recorded. Data are presented as medians (IQR). <b><i>Results:<\/i><\/b> The Hep<sub>(CB)<\/sub> of very preterm infants (GA <30 weeks, n = 40) was 26.9 ng\/ml (13.5-63.1), for moderately preterm infants (GA 30-36 weeks, n = 81) it was 45.9 ng\/ml (24.7-74.5) and for term infants (GA \u226537 weeks, n = 100) it was 103.9 ng\/ml (61.4-149.2). The Hep<sub>(CB)<\/sub> of infants with ID was lower [36.9 ng\/ml (18.0-58.3)] than that of iron-replete infants [86.6 ng\/ml (51.9-143.8)]. The Hep<sub>(CB)<\/sub> of infants delivered by elective caesarean section was lower [38.3 ng\/ml (15.5-73.7)] than that of infants after spontaneous vaginal delivery or secondary caesarean section [80.3 ng\/ml (48.5-137.6)]. Infants with a standard deviation score for birth weight (SDS<sub>BW<\/sub>) <-2 had a lower Hep<sub>(CB)<\/sub> [23.1 ng\/ml (11.7-61.5)] compared to infants with SDS<sub>BW<\/sub> \u2265-2 [71.1 ng\/ml (34.0-121.7)]. The highest Hep<sub>(CB)<\/sub> (437.6 ng\/ml) was recorded in an infant with <i>Enterococcus faecalis<\/i> sepsis. Multiple logistic regression analysis confirmed ferritin, GA and mode of delivery as important factors associated with Hep<sub>(CB)<\/sub>. <b><i>Conclusion:<\/i><\/b> This is the first report on GA-specific reference ranges for Hep<sub>(CB)<\/sub> in preterm infants. Whereas iron stores, GA and mode of delivery were associated with Hep<sub>(CB)<\/sub>, the association with inflammation and intra-uterine growth retardation was less clear.<\/jats:p>","DOI":"10.1159\/000360072","type":"journal-article","created":{"date-parts":[[2014,6,27]],"date-time":"2014-06-27T07:01:19Z","timestamp":1403852479000},"page":"133-139","source":"Crossref","is-referenced-by-count":26,"title":["Gestational Age-Specific Reference Ranges of Hepcidin in Cord Blood"],"prefix":"10.1159","volume":"106","author":[{"given":"Laila","family":"Lorenz","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Johanna","family":"Herbst","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Corinna","family":"Engel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andreas","family":"Peter","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Harald","family":"Abele","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1072-0066","authenticated-orcid":false,"given":"Christian F.","family":"Poets","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mark","family":"Westerman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Axel R.","family":"Franz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2014,6,27]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1159\/000353161"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1111\/ejh.12035"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1203\/01.PDR.0000091287.38691.EF"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2004-1680"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1159\/000108764"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2007-0495"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1097\/MPG.0b013e3181adaee0"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2011.12.030"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2008-02-139915"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1136\/adc.73.1.17"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.3945\/jn.112.162362"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0609.2010.01479.x"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2012.06.010"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.3945\/ajcn.111.013938"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1172\/JCI15686"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.2006.06216.x"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1126\/science.1104742"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2011.12.030"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1016\/j.placenta.2010.10.009"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1007\/s00535-010-0344-z"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1136\/adc.2006.097279"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2010-08-299859"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1172\/JCI200420945"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1111\/j.1651-2227.2001.tb01359.x"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1016\/j.earlhumdev.2004.10.017"}],"container-title":["Neonatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/360072","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/360072","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T17:27:32Z","timestamp":1745429252000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000360072"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014]]},"references-count":25,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2014,8,1]]},"published-print":{"date-parts":[[2014,8,7]]}},"URL":"https:\/\/doi.org\/10.1159\/000360072","archive":["Portico"],"relation":{},"ISSN":["1661-7800","1661-7819"],"issn-type":[{"value":"1661-7800","type":"print"},{"value":"1661-7819","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014]]}}}