{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T04:30:45Z","timestamp":1745469045313,"version":"3.40.4"},"reference-count":16,"publisher":"S. Karger AG","issue":"2","license":[{"start":{"date-parts":[[2014,1,1]],"date-time":"2014-01-01T00:00:00Z","timestamp":1388534400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2014,1,1]],"date-time":"2014-01-01T00:00:00Z","timestamp":1388534400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Dermatology"],"published-print":{"date-parts":[[2014]]},"abstract":"<b><i>Background:<\/i><\/b> Copy number variations of <i>FCGR3B<\/i> are associated with several immune related diseases such as systemic lupus erythematosus, rheumatoid arthritis and primary Sj\u00f6gren's syndrome. Little is known about the association between <i>FCGR3B<\/i> copy number variants and psoriasis. <b><i>Objective:<\/i><\/b> To investigate whether <i>FCGR3B<\/i> copy number variants are associated with susceptibility to psoriasis vulgaris in the Chinese Han population. <b><i>Methods:<\/i><\/b> 343 psoriasis vulgaris patients and 574 healthy individuals were recruited as cases and controls. TaqMan\u00ae Copy Number Assays were performed to quantify the copy numbers in the <i>FCGR3B<\/i> locus. CopyCaller v1.0 software and R (version 2.15.3) were used to do the subsequent statistical analysis. <b><i>Results:<\/i><\/b> A significant association between psoriasis vulgaris and a high copy number (>2) of <i>FCGR3B<\/i> was observed (odds ratio = 1.63, 95% confidence interval 1.09-2.45, p < 0.02). However, the low copy number of <i>FCGR3B<\/i> was not significantly associated with psoriasis vulgaris. <b><i>Conclusion:<\/i><\/b> A high copy number of <i>FCGR3B<\/i> is associated with psoriasis vulgaris in Han Chinese.<\/jats:p>","DOI":"10.1159\/000360160","type":"journal-article","created":{"date-parts":[[2014,7,10]],"date-time":"2014-07-10T06:47:52Z","timestamp":1404974872000},"page":"70-75","source":"Crossref","is-referenced-by-count":9,"title":["A High Copy Number of FCGR3B Is Associated with Psoriasis Vulgaris in Han Chinese"],"prefix":"10.1159","volume":"229","author":[{"given":"Yumei","family":"Wu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhou","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liming","family":"Tao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guoliang","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fatao","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ting","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Feng","family":"Xue","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yingwei","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lin","family":"He","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jie","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yun","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2014,7,10]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1016\/S0190-9622(84)80314-X"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-pathol-011811-132448"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-genet-102209-163544"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2249.2008.03865.x"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1186\/ar3731"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1002\/humu.22031"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.3899\/jrheum.120294"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1038\/gene.2009.71"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2012.04.037"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1177\/0961203309350319"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20072413"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1038\/nature04489"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1093\/intimm\/dxp113"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddq216"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1016\/j.cellimm.2006.07.007"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1002\/humu.20997"}],"container-title":["Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/360160","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/360160","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T17:28:05Z","timestamp":1745429285000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000360160"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014]]},"references-count":16,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2014,10,1]]},"published-print":{"date-parts":[[2014,10,30]]}},"URL":"https:\/\/doi.org\/10.1159\/000360160","archive":["Portico"],"relation":{},"ISSN":["1018-8665","1421-9832"],"issn-type":[{"type":"print","value":"1018-8665"},{"type":"electronic","value":"1421-9832"}],"subject":[],"published":{"date-parts":[[2014]]}}}