{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T01:09:22Z","timestamp":1793149762858,"version":"4.5.0"},"reference-count":34,"publisher":"S. Karger AG","issue":"5","license":[{"start":{"date-parts":[[2014,1,1]],"date-time":"2014-01-01T00:00:00Z","timestamp":1388534400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"},{"start":{"date-parts":[[2014,1,1]],"date-time":"2014-01-01T00:00:00Z","timestamp":1388534400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Intervirology"],"published-print":{"date-parts":[[2014]]},"abstract":"<jats:p>Objective: We report the infection of New Zealand white rabbits with Epstein-Barr virus (EBV). Methods: EBV prepared in B95-8 (producer) cells was inoculated to rabbits by combined intranasal and oral routes. Blood and white blood cell (WBC) samples were taken before infection, then on days 8, 28 and 98 post-infection (p.i.). Results: Administration of either 3 \u00d7 108 (group A, 11 rabbits) or 1 \u00d7 109 (group B, 10 rabbits) EBV DNA copies per animal induced subacute and\/or persistent infection. The IgG antibodies in plasma were detected by ELISA as well as by immunoblot (IB). The IB bands showed mainly antibodies to the BZRF1\/Zta transactivation polypeptide (69.2%), the p54 early protein (53.4%) and to the p23 capsid protein (35.8%). No anti-EBNA1 antibody was detected throughout. Viral DNA could be detected by PCR in WBCs and\/or spleen of 7 out of 21 infected rabbits (30%), while 60-80% of them showed serologic response. The transiently present EBV DNA was accompanied by LMP1 antigen. Conclusions: Rabbits developed persistent EBV infection in the absence of EBNA1 antibodies and by the lack of typical infectious mononucleosis-like syndrome. The absence of EBNA1 antibody may reflect the lack of EBNA1 in B cells of EBV-inoculated rabbits.<\/jats:p>","DOI":"10.1159\/000360223","type":"journal-article","created":{"date-parts":[[2014,6,30]],"date-time":"2014-06-30T13:05:22Z","timestamp":1404133522000},"page":"254-269","source":"Crossref","is-referenced-by-count":10,"title":["Epstein-Barr Virus (HHV-4) Inoculation to Rabbits by Intranasal and Oral Routes Results in Subacute and\/or Persistent Infection Dissimilar to Human Disease"],"prefix":"10.1159","volume":"57","author":[{"given":"Julius","family":"Raj\u010d\u00e1ni","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kalman","family":"Szenthe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vladimira","family":"\u010eurmanov\u00e1","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Agnes","family":"T\u00f3th","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Balazs","family":"\u00c1sv\u00e1nyi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ervin","family":"Pitlik","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laszlo","family":"Stipkovits","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan","family":"Szathmary","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2014,6,28]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V98.7.2193"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9440(10)64104-1"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9440(10)64306-4"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1007\/BF01322687"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1098\/rstb.2000.0779"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1556\/AMicr.52.2005.1.2"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1007\/978-0-387-34127-9_5"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1099\/vir.0.013300-0"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.2353\/ajpath.2008.071186"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btm044"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.21102"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.21597"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1002\/1096-9071(200104)63:4<271::AID-JMV1001>3.0.CO;2-T"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1017\/CBO9780511545313.052"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1038\/310207a0"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1155\/2010\/695104"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1017\/CBO9780511545313.051"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.00164-09"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.5501\/wjv.v1.i1.31"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1016\/S0928-0197(98)00061-0"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1017\/CBO9780511545313.026"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1093\/emboj\/19.12.3080"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1038\/ng1424"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1016\/S1074-7613(01)00226-6"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1099-1654(200003\/04)10:2<83::AID-RMV262>3.0.CO;2-T"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.3390\/v5010226"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.1093\/embo-reports\/kvd026"},{"key":"ref28","doi-asserted-by":"publisher","DOI":"10.1007\/3-540-31181-5_5"},{"key":"ref29","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.00013-12"},{"key":"ref30","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbagrm.2009.10.005"},{"key":"ref31","doi-asserted-by":"publisher","DOI":"10.1016\/j.virusres.2010.07.026"},{"key":"ref32","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejcb.2011.01.014"},{"key":"ref33","doi-asserted-by":"publisher","DOI":"10.1017\/CBO9780511545313.028"},{"key":"ref34","doi-asserted-by":"publisher","DOI":"10.1159\/000343753"}],"container-title":["Intervirology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/karger.com\/int\/article-pdf\/57\/5\/254\/3925904\/000360223.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/karger.com\/int\/article-pdf\/57\/5\/254\/3925904\/000360223.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T17:28:55Z","timestamp":1745429335000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000360223"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014]]},"references-count":34,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2014,8,1]]},"published-print":{"date-parts":[[2014,8,19]]}},"URL":"https:\/\/doi.org\/10.1159\/000360223","archive":["Portico"],"relation":{},"ISSN":["0300-5526","1423-0100"],"issn-type":[{"value":"0300-5526","type":"print"},{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