{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T06:07:56Z","timestamp":1789625276402,"version":"build-2803163510"},"reference-count":34,"publisher":"S. Karger AG","issue":"5","license":[{"start":{"date-parts":[[2014,1,1]],"date-time":"2014-01-01T00:00:00Z","timestamp":1388534400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2014,1,1]],"date-time":"2014-01-01T00:00:00Z","timestamp":1388534400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Innate Immun"],"published-print":{"date-parts":[[2014]]},"abstract":"<i>Listeria monocytogenes<\/i> is a facultative intracellular pathogen which can infect<i> Drosophila melanogaster<\/i>. Upon infection, <i>Drosophila<\/i> mounts an immune response including antimicrobial peptide production and autophagy activation. A set of previously published results prompted us to study the role of the deubiquitinating enzyme dUSP36 in response to <i>L. monocytogenes<\/i> infections. We show in this report that flies with <i>dUsp36<\/i>-specific inactivation in hemocytes are susceptible to <i>L. monocytogenes<\/i> infections (as are flies with autophagy-deficient hemocytes) but are still able to control bacterial growth. Interestingly, flies with <i>dUsp36<\/i>-depleted hemocytes are not sensitized to infection by other pathogens. We conclude that <i>dUsp36<\/i> plays a major role in hemocytes for tolerance to <i>L. monocytogenes<\/i>.<\/jats:p>","DOI":"10.1159\/000360293","type":"journal-article","created":{"date-parts":[[2014,4,23]],"date-time":"2014-04-23T06:43:23Z","timestamp":1398235403000},"page":"632-638","source":"Crossref","is-referenced-by-count":9,"title":["The <b><i>Drosophila<\/i><\/b> Deubiquitinating Enzyme dUSP36 Acts in the Hemocytes for Tolerance to <b><i>Listeria monocytogenes<\/i><\/b> Infections"],"prefix":"10.1159","volume":"6","author":[{"given":"Emmanuel","family":"Taillebourg","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David S.","family":"Schneider","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie-Odile","family":"Fauvarque","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2014,4,23]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.14.3.584-640.2001"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1078\/1438-4221-00111"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1084\/jem.167.4.1459"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.68.2.999-1003.2000"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(92)90188-I"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.109.4.1597"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1046\/j.1462-5822.2003.00329.x"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1038\/nri2194"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.immunol.25.022106.141615"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1038\/414756a"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1126\/science.1085432"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1038\/ni1123"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1016\/S1074-7613(04)00104-9"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1038\/ni1356"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.92.21.9465"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1101\/gad.203301"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1038\/ni.1634"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1101\/gad.1599207"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1038\/nri2161"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-immunol-020711-075030"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1126\/science.1214935"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1534\/genetics.107.083782"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pbio.1000150"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1016\/j.chom.2009.09.007"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.4161\/auto.19381"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0506461102"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.1016\/j.ydbio.2003.06.001"},{"key":"ref28","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1208156"},{"key":"ref29","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0403789101"},{"key":"ref30","doi-asserted-by":"publisher","DOI":"10.1126\/science.1089035"},{"key":"ref31","doi-asserted-by":"publisher","DOI":"10.1016\/j.micinf.2009.03.004"},{"key":"ref32","doi-asserted-by":"publisher","DOI":"10.1159\/000210264"},{"key":"ref33","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.049155"},{"key":"ref34","doi-asserted-by":"publisher","DOI":"10.1016\/j.cub.2006.08.052"}],"container-title":["Journal of Innate Immunity"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/360293","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/360293","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T17:29:32Z","timestamp":1745429372000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000360293"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014]]},"references-count":34,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2014,8,1]]},"published-print":{"date-parts":[[2014,8,12]]}},"URL":"https:\/\/doi.org\/10.1159\/000360293","archive":["Portico"],"relation":{"is-supplemented-by":[{"id-type":"doi","id":"10.6084\/m9.figshare.5126299","asserted-by":"subject"}]},"ISSN":["1662-811X","1662-8128"],"issn-type":[{"value":"1662-811X","type":"print"},{"value":"1662-8128","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014]]}}}