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Growth retardation, deafness and hearing loss have also been described in CoQ&lt;sub&gt;10&lt;\/sub&gt;-deficient patients. This heterogeneity in the clinical presentations suggests that multiple pathomechanisms may exist. To investigate the biochemical and molecular consequences of CoQ&lt;sub&gt;10&lt;\/sub&gt; deficiency, different laboratories have studied cultures of skin fibroblasts from patients with CoQ&lt;sub&gt;10&lt;\/sub&gt; deficiency. 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